1. Panels
  2. Inherited renal cancer
  3. MITF
STRs in panel
Prev Next
Regions in panel
Prev Next

Inherited renal cancer

Gene: MITF

Amber List (moderate evidence)
MITF (melanogenesis associated transcription factor)
EnsemblGeneIds (GRCh38): ENSG00000187098
EnsemblGeneIds (GRCh37): ENSG00000187098
OMIM: 156845, Gene2Phenotype
MITF is in 9 panels

2 reviews

Ivone Leong (Genomics England Curator)

As discussed in the GMS Inherited Cancer Specialist Test Group webex call 31st Jan 2019: The Specialist Test Group agreed that this gene should be rated amber.
Created: 31 Jul 2019, 12:51 p.m. | Last Modified: 31 Jul 2019, 12:56 p.m.
Panel Version: 0.38
Created: 31 Jul 2019, 12:51 p.m.
Last Modified: 31 Jul 2019, 12:56 p.m.
Panel version: 0.38

Rachel Robinson (Leeds Genetics Laboratory)

I don't know

Variants in this GENE are reported as part of current diagnostic practice

Created: 28 Dec 2018, 11:48 a.m.

Panel version: 0.1

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Amber
Phenotypes
  • {Melanoma, cutaneous malignant, susceptibility to, 8}, OMIM:614456
  • Renal cell carcinoma (disease), MONDO:0005086
OMIM
156845
Clinvar variants
Variants in MITF
Penetrance
None
Publications
Panels with this gene

History Filter Activity

8 Mar 2021, Gel status: 2

Set Phenotypes

Arina Puzriakova (Genomics England Curator)

Phenotypes for gene: MITF were changed from to {Melanoma, cutaneous malignant, susceptibility to, 8}, OMIM:614456; Renal cell carcinoma (disease), MONDO:0005086

8 Mar 2021, Gel status: 2

Set publications

Arina Puzriakova (Genomics England Curator)

Publications for gene: MITF were set to 27899189

15 Oct 2019, Gel status: 2

Set publications

Rebecca Foulger (Genomics England curator)

Publications for gene: MITF were set to PMID: 27899189

30 Jan 2019, Gel status: 2

Entity classified by Genomics England curator

Ivone Leong (Genomics England Curator)

Gene: mitf has been classified as Amber List (Moderate Evidence).

28 Dec 2018, Gel status: 0

Created, Added New Source, Set mode of inheritance, Set publications

Rachel Robinson (Leeds Genetics Laboratory)

gene: MITF was added gene: MITF was added to Inherited renal cancer. Sources: UKGTN Mode of inheritance for gene: MITF was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Publications for gene: MITF were set to PMID: 27899189 gene: MITF was marked as current diagnostic