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  2. Inherited renal cancer
  3. TMEM127
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Inherited renal cancer

Gene: TMEM127

Amber List (moderate evidence)
TMEM127 (transmembrane protein 127)
EnsemblGeneIds (GRCh38): ENSG00000135956
EnsemblGeneIds (GRCh37): ENSG00000135956
OMIM: 613403, Gene2Phenotype
TMEM127 is in 7 panels

2 reviews

Ivone Leong (Genomics England Curator)

As discussed in the GMS Inherited Cancer Specialist Test Group webex call 31st Jan 2019: The Specialist Test Group agreed that this gene should be rated amber.
Created: 1 Feb 2019, 9:47 a.m. | Last Modified: 31 Jul 2019, 12:55 p.m.
Panel Version: 0.38
Created: 1 Feb 2019, 9:47 a.m.
Last Modified: 31 Jul 2019, 12:55 p.m.
Panel version: 0.33

Rachel Robinson (Leeds Genetics Laboratory)

Green List (high evidence)

Sources: UKGTN
Created: 28 Dec 2018, 11:35 a.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Publications

Variants in this GENE are reported as part of current diagnostic practice

Created: 28 Dec 2018, 11:35 a.m.

Panel version: 0.1

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Amber
Phenotypes
  • Renal cell carcinoma (disease), MONDO:0005086
OMIM
613403
Clinvar variants
Variants in TMEM127
Penetrance
None
Publications
Panels with this gene

History Filter Activity

8 Mar 2021, Gel status: 2

Set Phenotypes

Arina Puzriakova (Genomics England Curator)

Phenotypes for gene: TMEM127 were changed from to Renal cell carcinoma (disease), MONDO:0005086

15 Oct 2019, Gel status: 2

Set publications

Rebecca Foulger (Genomics England curator)

Publications for gene: TMEM127 were set to PMID: 24334765

1 Feb 2019, Gel status: 2

Entity classified by Genomics England curator

Ivone Leong (Genomics England Curator)

Gene: tmem127 has been classified as Amber List (Moderate Evidence).

30 Jan 2019, Gel status: 3

Entity classified by Genomics England curator

Ivone Leong (Genomics England Curator)

Gene: tmem127 has been classified as Green List (High Evidence).

28 Dec 2018, Gel status: 0

Created, Added New Source, Set mode of inheritance, Set publications

Rachel Robinson (Leeds Genetics Laboratory)

gene: TMEM127 was added gene: TMEM127 was added to Inherited renal cancer. Sources: UKGTN Mode of inheritance for gene: TMEM127 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Publications for gene: TMEM127 were set to PMID: 24334765 Review for gene: TMEM127 was set to GREEN gene: TMEM127 was marked as current diagnostic