Genes in panel
- ACD 4
- ACP5 5
- ADA 9
- ADA2 5
- ADAM17 7
- ADAR 4
- AGR2 3
- AICDA 7
- AIRE 6
- AK2 7
- ALPI 4
- ALPK1 2
- ANKZF1 3
- AP3B1 5
- ARPC1B 5
- ARPC5 3
- ATM 4
- ATP6AP1 4
- B2M 5
- BACH2 5
- BCL10 6
- BLM 4
- BLNK 7
- BLOC1S6 5
- BTK 8
- C17orf62 4
- C1QA 4
- C1QB 5
- C1QC 4
- C1R 4
- C1S 4
- C2 7
- C2orf69 3
- C3 4
- C4A 4
- C4B 4
- C5 4
- C6 4
- C7 4
- C8A 4
- C8B 4
- C9 4
- CARD11 5
- CARD14 5
- CARD9 4
- CARMIL2 6
- CASP8 5
- CBLB 3
- CCBE1 5
- CD19 6
- CD247 9
- CD27 6
- CD3D 8
- CD3E 8
- CD3G 5
- CD4 7
- CD40 5
- CD40LG 5
- CD46 4
- CD55 4
- CD59 4
- CD70 5
- CD79A 7
- CD79B 6
- CD81 5
- CDC42 3
- CDCA7 4
- CEBPE 5
- CFD 4
- CFH 4
- CFI 4
- CFP 4
- CHD7 4
- CIB1 3
- CIITA 6
- CLPB 5
- COL7A1 4
- COPA 6
- CORO1A 7
- CR2 6
- CREBBP 3
- CSF2RA 4
- CSF2RB 5
- CSF3R 6
- CTLA4 7
- CTPS1 5
- CTSC 4
- CXCR2 6
- CXCR4 6
- CYBA 4
- CYBB 5
- DBR1 3
- DCLRE1C 8
- DEF6 5
- DIAPH1 3
- DKC1 4
- DNAJC21 4
- DNASE1L3 7
- DNASE2 4
- DNMT3B 6
- DOCK11 3
- DOCK2 5
- DOCK8 7
- DPP9 3
- DUT 3
- EFL1 3
- ELANE 6
- ELF4 9
- EP300 3
- EPG5 6
- ERCC6L2 4
- EXTL3 6
- F12 4
- FADD 5
- FAS 5
- FASLG 6
- FAT4 5
- FCHO1 4
- FERMT1 2
- FERMT3 4
- FNIP1 2
- FOXN1 9
- FOXP3 5
- G6PC3 6
- G6PD 4
- GATA1 5
- GATA2 4
- GFI1 6
- GINS1 4
- GNAI2 3
- GUCY2C 5
- HAVCR2 4
- HAX1 8
- HELLS 4
- HMOX1 5
- HPS1 4
- HPS4 4
- HPS6 4
- HTRA2 5
- HYOU1 6
- ICOS 7
- IFIH1 4
- IFNAR1 3
- IFNAR2 5
- IFNGR1 4
- IFNGR2 4
- IGHM 6
- IGLL1 6
- IKBKB 8
- IKBKG 5
- IKZF1 6
- IKZF2 4
- IKZF3 2
- IL10 5
- IL10RA 5
- IL10RB 5
- IL12B 4
- IL12RB1 4
- IL17RA 5
- IL17RC 4
- IL1RN 6
- IL21R 5
- IL23R 5
- IL2RA 5
- IL2RB 4
- IL2RG 8
- IL36RN 6
- IL6R 6
- IL6ST 7
- IL7 2
- IL7R 8
- IRAK4 4
- IRF1 3
- IRF2BP2 5
- IRF4 5
- IRF7 4
- IRF8 4
- ISG15 4
- ITCH 5
- ITGB2 4
- ITK 7
- ITPR3 2
- JAGN1 4
- JAK1 6
- JAK3 8
- KDM6A 5
- KMT2A 4
- KMT2D 5
- LACC1 3
- LAMTOR2 6
- LAT 6
- LCK 5
- LCP2 5
- LIG1 6
- LIG4 8
- LPIN2 6
- LRBA 6
- LYN 3
- LYST 6
- MAGT1 7
- MALT1 6
- MAP3K14 6
- MCM4 7
- MCTS1 3
- MECOM 3
- MEFV 6
- MOGS 5
- MPEG1 2
- MSN 5
- MTHFD1 6
- MVK 6
- MYD88 6
- MYO5B 8
- MYSM1 5
- NBN 5
- NCF1 5
- NCF2 5
- NCF4 6
- NCKAP1L 2
- NFAT5 6
- NFE2L2 4
- NFKB1 5
- NFKB2 7
- NFKBIA 6
- NHEJ1 10
- NHP2 5
- NLRC4 6
- NLRP1 10
- NLRP12 6
- NLRP3 6
- NOD2 7
- NPC1 3
- NSMCE3 4
- NUDCD3 2
- OAS1 5
- ORAI1 8
- OTULIN 8
- PARN 5
- PAX1 3
- PEPD 5
- PGM3 5
- PI4KA 2
- PIK3CD 10
- PIK3CG 3
- PIK3R1 8
- PLCG2 9
- PLG 3
- PNP 7
- POLA1 5
- POLD1 6
- POLE 6
- POMP 2
- PRF1 5
- PRIM1 3
- PRKCD 6
- PRKDC 5
- PSMB10 7
- PSMB8 6
- PSTPIP1 6
- PTCRA 3
- PTPN2 5
- PTPRC 8
- RAB27A 6
- RAC2 9
- RAG1 8
- RAG2 8
- RANBP2 4
- RASGRP1 6
- RBCK1 6
- RECQL4 4
- REL 5
- RELA 6
- RELB 6
- RFX5 6
- RFXANK 6
- RFXAP 6
- RIPK1 7
- RMRP 8
- RNASEH2A 5
- RNASEH2B 5
- RNASEH2C 5
- RNF168 5
- RNU7-1 3
- RORC 5
- RPSA 5
- RTEL1 5
- SAMD9 4
- SAMD9L 7
- SAMHD1 5
- SASH3 4
- SBDS 6
- SEC61A1 7
- SERPING1 5
- SGPL1 5
- SH2D1A 5
- SKIV2L 6
- SLC29A3 5
- SLC35C1 5
- SLC37A4 6
- SLC39A4 4
- SLC39A7 5
- SLC46A1 5
- SLC7A7 4
- SLCO2A1 3
- SMARCAL1 6
- SMARCD2 4
- SNORA31 4
- SOCS1 2
- SP110 5
- SPI1 5
- SPINK5 6
- SPPL2A 5
- SRP54 4
- STAT1 5
- STAT2 5
- STAT3 5
- STAT4 6
- STAT5B 10
- STAT6 5
- STIM1 6
- STK4 6
- STX11 5
- STXBP2 5
- STXBP3 4
- SYK 3
- TAP1 5
- TAP2 5
- TAZ 6
- TBK1 7
- TBX1 9
- TCF3 10
- TCN2 10
- TET2 5
- TFRC 7
- TGFB1 4
- TGFBR1 2
- TGFBR2 2
- TICAM1 5
- TLR3 5
- TLR7 4
- TLR8 5
- TMC6 5
- TMC8 5
- TMEFF1 3
- TMEM173 7
- TNFAIP3 5
- TNFRSF1A 6
- TNFRSF9 4
- TOP2B 4
- TPP2 5
- TRAC 5
- TRAF3 5
- TRAF3IP2 8
- TREX1 5
- TRIM22 4
- TRNT1 4
- TTC37 6
- TTC7A 5
- TYK2 5
- UNC13D 5
- UNC93B1 5
- UNG 5
- USB1 4
- USP18 7
- VPS13B 5
- VPS45 5
- WAS 8
- WDR1 7
- WIPF1 5
- XIAP 6
- ZAP70 7
- ZBTB24 5
- ZNF341 5
- ZNFX1 4
- ANGPT1 2
- AP1S3 5
- AP3D1 3
- ATAD3A 2
- BCL11B 4
- CARD8 2
- CASP10 7
- CD8A 4
- CFB 4
- CFTR 3
- CTC1 4
- DCLRE1B 8
- ERBIN 3
- FCGR3A 3
- FGL2 2
- FLT3LG 3
- FMNL2 2
- FOXI3 2
- FPR1 2
- GCC2 2
- GIMAP5 5
- GTF3A 2
- HSPA1L 6
- IGKC 2
- IL17F 3
- IL1R1 2
- IL21 4
- IL27RA 3
- IPO8 3
- IRF3 2
- IRF9 2
- ITGAV 1
- ITPKB 2
- IVNS1ABP 3
- KCNA5 2
- KRAS 2
- MAN2B2 4
- MBL2 2
- MKL1 4
- MPO 3
- NCSTN 2
- NOP10 4
- NRAS 5
- POLD3 2
- POLR3A 2
- POLR3C 2
- PSENEN 3
- PSMA3 5
- PSMB4 5
- PSMB9 5
- PTEN 5
- QSOX2 1
- RC3H1 3
- REXO2 2
- RHBDF2 2
- RHOH 4
- RNF31 6
- RNU4ATAC 3
- SCGN 2
- SENP7 1
- SLC30A2 2
- SLC9A3 3
- SRP72 2
- TAPBP 3
- TERC 3
- TERT 3
- TINF2 3
- TNFRSF11A 4
- TNFRSF13C 2
- ABI3 1
- ACTB 2
- AMFR 2
- APOL1 2
- ARHGAP42 2
- ARHGEF1 2
- ASXL1 2
- ATG4A 2
- BRCA1 0
- BRCA2 0
- C8G 2
- CARD10 2
- CD274 2
- CD28 2
- CFHR1 4
- CFHR2 2
- CFHR3 4
- CFHR4 4
- CFHR5 6
- CHUK 2
- CLCN7 2
- CNBP 4
- COLEC11 2
- COPG1 2
- CRACR2A 2
- CSF2 2
- CTNNBL1 3
- CXorf36 1
- EPCAM 2
- ERCC2 2
- ERCC3 2
- ERCC4 0
- EZR 2
- FAAP24 3
- FANCF 0
- FANCI 0
- FANCM 0
- FBF1 2
- FBRS 1
- FCGR1A 2
- FCGR2A 2
- FCGR2B 2
- FCGR3B 4
- FCGRT 2
- FCN3 4
- FOXM1 1
- FPR2 2
- FPR3 2
- GAD1 5
- GIMAP6 2
- GTF2H5 1
- HCK 2
- HS3ST6 2
- ICOSLG 4
- IFNG 2
- IGHG2 2
- IL12RB2 2
- IL17A 2
- IL18 2
- IL18BP 2
- IL22 2
- IL23A 2
- IL31RA 1
- IL37 2
- IL6 1
- INO80 6
- IRAK1 2
- ITGAM 2
- LRRC32 2
- LRRC8A 5
- LSM11 2
- LYZ 2
- MAP1LC3B2 2
- MAPK8 2
- MASP1 2
- MASP2 4
- MCM10 2
- MED13L 1
- MICA 1
- MPI 2
- MR1 2
- MRE11 3
- MS4A1 3
- MSH6 3
- MTPAP 1
- MYOF 2
- NBAS 2
- NFKBID 3
- NOS2 2
- ODC1 1
- OSTM1 2
- PARP1 1
- PDCD1 2
- PLEKHM1 2
- PMS2 5
- POLD2 2
- POLE2 2
- POLR3F 2
- POU2AF1 2
- PSEN1 3
- PSMG2 2
- PTPN22 1
- RAD50 2
- RAP1B 2
- RELN 1
- RET 3
- RGS10 2
- RHOG 2
- SAMD3 1
- SART3 3
- SEMA3E 3
- SH3BP2 3
- SH3KBP1 2
- SIRT1 2
- SLC13A4 1
- SNX10 1
- STAT5A 3
- STN1 1
- TBX21 2
- TCIRG1 1
- THBD 3
- TIRAP 2
- TLN1 1
- TNFRSF13B 8
- TNFRSF4 3
- TNFSF11 1
- TNFSF12 2
- TNFSF13 1
- TNFSF9 2
- TNIP1 1
- TOM1 2
- TSPAN14 1
- TUBGCP3 1
- UBA1 5
- UNC119 3
- WRAP53 1
- ZC3HC1 1
- ZFP36 1
- ZNF34 1
- GTF3AP5 1
STRs in panel
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Primary immunodeficiency or monogenic inflammatory bowel disease
Gene: FGL2 Amber List (moderate evidence)
FGL2 (fibrinogen like 2)
EnsemblGeneIds (GRCh38): ENSG00000127951
EnsemblGeneIds (GRCh37): ENSG00000127951
OMIM: 605351, Gene2Phenotype
FGL2 is in 1 panel
EnsemblGeneIds (GRCh38): ENSG00000127951
EnsemblGeneIds (GRCh37): ENSG00000127951
OMIM: 605351, Gene2Phenotype
FGL2 is in 1 panel
2 reviews
Achchuthan Shanmugasundram (Genomics England Curator)
I don't know
Comment on list classification: As reviewed by Boaz Palterer and reported in PMID:36243222, there is a child with early-onset systemic inflammation, autoantibodies, and vasculitis and homozygous truncating FGL2 variant and functional evidence are available in support of the disease association. Hence, this gene should be rated amber with current evidence.Created: 10 Jan 2024, 1:54 p.m. | Last Modified: 10 Jan 2024, 1:54 p.m.
Panel Version: 4.162
Comment on phenotypes: This gene has not yet been associated with relevant phenotypes either in OMIM or in Gene2Phenotype.Created: 10 Jan 2024, 1:51 p.m. | Last Modified: 10 Jan 2024, 1:51 p.m.
Panel Version: 4.161
Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal
Phenotypes
autoinflammatory syndrome, MONDO:0019751
Publications
Created: 10 Jan 2024, 1:46 p.m.
Last Modified: 10 Jan 2024, 1:46 p.m.
Panel version: 4.159
Last Modified: 10 Jan 2024, 1:46 p.m.
Panel version: 4.159
Boaz Palterer (University of Florence)
Red List (low evidence)
One subject from one kindred with homozygous truncating FGL2 variant. Some in vitro phenotype rescue and mouse model.
Sources: LiteratureCreated: 24 Oct 2023, 7:24 p.m.
Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal
Phenotypes
immunedysregulation; autoimmunity; arthritis; Treg dysfunction; leukocytoclastic vasculitis
Publications
Created: 24 Oct 2023, 7:24 p.m.
Panel version: 4.57
Panel version: 4.57
Details
- Mode of Inheritance
- BIALLELIC, autosomal or pseudoautosomal
- Sources
-
- Expert Review Amber
- Phenotypes
-
- autoinflammatory syndrome, MONDO:0019751
- OMIM
- 605351
- Clinvar variants
- Variants in FGL2
- Penetrance
- unknown
- Publications
- Panels with this gene
History Filter Activity
10 Jan 2024, Gel status: 2
Entity classified by Genomics England curator
Achchuthan Shanmugasundram (Genomics England Curator)Gene: fgl2 has been classified as Amber List (Moderate Evidence).
10 Jan 2024, Gel status: 0
Set Phenotypes
Achchuthan Shanmugasundram (Genomics England Curator)Phenotypes for gene: FGL2 were changed from autoinflammatory syndrome, MONDO:0019751 to autoinflammatory syndrome, MONDO:0019751
10 Jan 2024, Gel status: 0
Set Phenotypes
Achchuthan Shanmugasundram (Genomics England Curator)Phenotypes for gene: FGL2 were changed from immunedysregulation; autoimmunity; arthritis; Treg dysfunction; leukocytoclastic vasculitis to autoinflammatory syndrome, MONDO:0019751
24 Oct 2023, Gel status: 0
Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes, Set penetrance
Boaz Palterer (University of Florence)gene: FGL2 was added gene: FGL2 was added to Primary immunodeficiency or monogenic inflammatory bowel disease. Sources: Literature Mode of inheritance for gene: FGL2 was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: FGL2 were set to 36243222 Phenotypes for gene: FGL2 were set to immunedysregulation; autoimmunity; arthritis; Treg dysfunction; leukocytoclastic vasculitis Penetrance for gene: FGL2 were set to unknown Review for gene: FGL2 was set to RED