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STRs in panel
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Primary immunodeficiency

Gene: IL6

Red List (low evidence)

IL6 (interleukin 6)
EnsemblGeneIds (GRCh38): ENSG00000136244
EnsemblGeneIds (GRCh37): ENSG00000136244
OMIM: 147620, Gene2Phenotype
IL6 is in 6 panels

1 review

Ellen McDonagh (Genomics England Curator)

Red List (low evidence)

Not yet peer-reviewed study available in medRxiv: https://www.medrxiv.org/content/10.1101/2020.04.01.20047381v1
reports an association between elevated interleukin-6 (IL-6) in COVID-19 infected patients with the need for mechanical ventilation (p=1.2.10-5). The maximal IL-6 level (cutoff 80 pg/ml) for each patient during disease predicted respiratory failure with high accuracy (p=1.7.10-8, AUC=0.98). The risk of respiratory failure for patients with IL-6 levels of ≥ 80 pg/ml was 22 times higher compared to patients with lower IL-6 levels.
Sources: Literature
Created: 8 Apr 2020, 9:34 a.m.

Mode of inheritance
Unknown

Phenotypes
Potential marker for respiratory failure when infected with COVID-19

Publications

Details

Mode of Inheritance
Unknown
Sources
  • Literature
Phenotypes
  • Potential marker for respiratory failure when infected with COVID-19
OMIM
147620
Clinvar variants
Variants in IL6
Penetrance
None
Publications
Panels with this gene

History Filter Activity

8 Apr 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Ellen McDonagh (Genomics England Curator)

gene: IL6 was added gene: IL6 was added to Primary immunodeficiency. Sources: Literature Mode of inheritance for gene: IL6 was set to Unknown Publications for gene: IL6 were set to medRxiv 2020.04.01.20047381; doi: https://doi.org/10.1101/2020.04.01.20047381 Phenotypes for gene: IL6 were set to Potential marker for respiratory failure when infected with COVID-19 Review for gene: IL6 was set to RED