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Primary immunodeficiency

Gene: IL37

Red List (low evidence)

IL37 (interleukin 37)
EnsemblGeneIds (GRCh38): ENSG00000125571
EnsemblGeneIds (GRCh37): ENSG00000125571
OMIM: 605510, Gene2Phenotype
IL37 is in 2 panels

2 reviews

Arina Puzriakova (Genomics England Curator)

Comment on list classification: Rating Red awaiting further evidence, as only a single case reported to date (PMID: 33674380)
Created: 27 Apr 2021, 2:25 p.m. | Last Modified: 27 Apr 2021, 2:25 p.m.
Panel Version: 2.417

Zornitza Stark (Australian Genomics)

Red List (low evidence)

Single family reported with homozygous truncating variant this gene and infantile-onset of IBD, some functional data.
Sources: Literature
Created: 17 Apr 2021, 1:29 a.m.

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Infantile inflammatory bowel disease



Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
  • Expert Review Red
  • Infantile inflammatory bowel disease
Clinvar variants
Variants in IL37
Panels with this gene

History Filter Activity

27 Apr 2021, Gel status: 1

Entity classified by Genomics England curator

Arina Puzriakova (Genomics England Curator)

Gene: il37 has been classified as Red List (Low Evidence).

17 Apr 2021, Gel status: 0

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Zornitza Stark (Australian Genomics)

gene: IL37 was added gene: IL37 was added to Primary immunodeficiency. Sources: Literature Mode of inheritance for gene: IL37 was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: IL37 were set to 33674380 Phenotypes for gene: IL37 were set to Infantile inflammatory bowel disease Review for gene: IL37 was set to RED