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STRs in panel
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Primary immunodeficiency

Gene: IL22

Red List (low evidence)

IL22 (interleukin 22)
EnsemblGeneIds (GRCh38): ENSG00000127318
EnsemblGeneIds (GRCh37): ENSG00000127318
OMIM: 605330, Gene2Phenotype
IL22 is in 5 panels

2 reviews

Sophie Hambleton (Newcastle University)

Red List (low evidence)

No association with human disease identified yet
Created: 20 Jun 2018, 7:27 p.m.

Louise Daugherty (Genomics England Curator)

I don't know

Comment on list classification: Changed from Amber to Red, no published cases of immunodeficiency to date. Red review from external expert review. Referred back to GRID for evidences.
Created: 21 Jun 2018, 3:04 p.m.
This gene was absent from the original PanelApp PID panel dataset (review April 2018). However it was listed in external expert immunodeficiency diagnostic gene list(s) GOSH or GRID. In this combined PID panel, this gene has been rated as AMBER and needs further curational review to assess pertinence prior to v1.
Created: 20 Apr 2018, 12:25 p.m.
Original metadata supplied by GRID. GRID Gene Symbol HGNC PanelApp check: IL22, GRID_Gene_Symbol: IL22, GRID_Transcript_ENS_Community submitted: ENST00000538666, GRID_Transcript_RefSeq: NM_020525, GRID_Transcript_ENS_used_on_Production: ENST00000538666
Created: 17 Apr 2018, 12:12 p.m.

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Red
  • GRID V2.0
Phenotypes
  • AutoAb Chronic Mucocutaneous Candidiasis
OMIM
605330
Clinvar variants
Variants in IL22
Penetrance
None
Panels with this gene

History Filter Activity

12 Jul 2018, Gel status: 1

Panel promoted to version 1.0

Louise Daugherty (Genomics England Curator)

2018-07-12 Louise Daugherty (Genomics England Curator) promoted panel to v1.0. Reviews were assessed, and panel was revised according to expert reviews and further in-house curation based on PanelApp guidelines. Previous panels (A- or hypo-gammaglobulinaemia, Congenital neutropaenia, Agranulocytosis, Combined B and T cell defect, Inherited complement deficiency and SCID panels) that were merged with this panel, were checked again for any changes/new reviews prior to versioning of this panel, these merged panels are now retired/made internal.

21 Jun 2018, Gel status: 1

Entity classified by Genomics England curator

Louise Daugherty (Genomics England Curator)

Gene: il22 has been classified as Red List (Low Evidence).

21 Jun 2018, Gel status: 1

Entity classified by Genomics England curator

Louise Daugherty (Genomics England Curator)

Gene: il22 has been classified as Red List (Low Evidence).

20 Apr 2018, Gel status: 2

Added New Source

Louise Daugherty (Genomics England Curator)

Expert Review Amber was added to IL22. Panel: Primary immunodeficiency disorders

17 Apr 2018, Gel status: 1

Set penetrance

Louise Daugherty (Genomics England Curator)

Phenotypes for gene IL22 were set to AutoAb Chronic Mucocutaneous Candidiasis

17 Apr 2018, Gel status: 1

Added New Source

Louise Daugherty (Genomics England Curator)

IL22 was added to Primary immunodeficiency disorders panel. Sources: GRID V2.0

17 Apr 2018, Gel status: 1

Created

Louise Daugherty (Genomics England Curator)

IL22 was created by Louise Daugherty