Primary immunodeficiency or monogenic inflammatory bowel disease
Gene: TRIM22The rating of this gene has been updated following NHS Genomic Medicine Service approval.Created: 4 Mar 2022, 10:17 a.m. | Last Modified: 4 Mar 2022, 10:17 a.m.
Panel Version: 2.529
Comment on list classification: Changed rating from Green to Amber so that Green genes on this panel reflect the NHS signed-off version. This will be reviewed at the next GMS panel update (added 'for-review' tag).Created: 20 Oct 2020, 3:45 p.m. | Last Modified: 20 Oct 2020, 3:45 p.m.
Panel Version: 2.363
Comment on list classification: Promoted from Red to Green based on expert review and evidence.Created: 15 Apr 2020, 3:25 p.m. | Last Modified: 15 Apr 2020, 3:25 p.m.
Panel Version: 2.72
Three unrelated families reported with bi-allelic variants in this gene, and very early onset IBD, some functional data. This gene is on our IBD panel.Created: 12 Apr 2020, 4:24 a.m. | Last Modified: 12 Apr 2020, 4:24 a.m.
Panel Version: 2.51
Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal
Phenotypes
Inflammatory bowel disease
Publications
Added publication referenced by IUIS december 2019 updateCreated: 28 Feb 2020, 8:49 p.m. | Last Modified: 28 Feb 2020, 8:49 p.m.
Panel Version: 2.36
Publications
Tag gene-checked tag was added to gene: TRIM22.
Tag for-review was removed from gene: TRIM22.
Source Expert Review Green was added to TRIM22. Rating Changed from Amber List (moderate evidence) to Green List (high evidence)
Gene: trim22 has been classified as Amber List (Moderate Evidence).
Tag for-review tag was added to gene: TRIM22.
Gene: trim22 has been classified as Green List (High Evidence).
Phenotypes for gene: TRIM22 were changed from Autoinflammatory Disorders; Granulomatous colitis; Diseases of Immune Dysregulation; TRIM22 to Autoinflammatory Disorders; Granulomatous colitis; Diseases of Immune Dysregulation; TRIM22; Inflammatory bowel disease
Publications for gene TRIM22 were updated from 32048120; 32086639 to 26836588; 32086639; 32048120
gene: TRIM22 was added gene: TRIM22 was added to Primary immunodeficiency. Sources: IUIS Classification December 2019 Mode of inheritance for gene: TRIM22 was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: TRIM22 were set to 32048120; 32086639 Phenotypes for gene: TRIM22 were set to Autoinflammatory Disorders; Granulomatous colitis; Diseases of Immune Dysregulation; TRIM22