Primary immunodeficiency or monogenic inflammatory bowel disease
Gene: TRIM22EnsemblGeneIds (GRCh38): ENSG00000132274
EnsemblGeneIds (GRCh37): ENSG00000132274
OMIM: 606559, Gene2Phenotype
TRIM22 is in 3 panels
4 reviews
Arina Puzriakova (Genomics England Curator)
The rating of this gene has been updated following NHS Genomic Medicine Service approval.Created: 4 Mar 2022, 10:17 a.m. | Last Modified: 4 Mar 2022, 10:17 a.m.
Panel Version: 2.529
Comment on list classification: Changed rating from Green to Amber so that Green genes on this panel reflect the NHS signed-off version. This will be reviewed at the next GMS panel update (added 'for-review' tag).Created: 20 Oct 2020, 3:45 p.m. | Last Modified: 20 Oct 2020, 3:45 p.m.
Panel Version: 2.363
Ivone Leong (Genomics England Curator)
Comment on list classification: Promoted from Red to Green based on expert review and evidence.Created: 15 Apr 2020, 3:25 p.m. | Last Modified: 15 Apr 2020, 3:25 p.m.
Panel Version: 2.72
Zornitza Stark (Australian Genomics)
Three unrelated families reported with bi-allelic variants in this gene, and very early onset IBD, some functional data. This gene is on our IBD panel.Created: 12 Apr 2020, 4:24 a.m. | Last Modified: 12 Apr 2020, 4:24 a.m.
Panel Version: 2.51
Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal
Phenotypes
Inflammatory bowel disease
Publications
Louise Daugherty (Genomics England Curator)
Added publication referenced by IUIS december 2019 updateCreated: 28 Feb 2020, 8:49 p.m. | Last Modified: 28 Feb 2020, 8:49 p.m.
Panel Version: 2.36
Publications
Details
- Mode of Inheritance
- BIALLELIC, autosomal or pseudoautosomal
- Sources
-
- Expert Review Green
- IUIS Classification December 2019
- Phenotypes
-
- Autoinflammatory Disorders
- Granulomatous colitis
- Diseases of Immune Dysregulation
- TRIM22
- Inflammatory bowel disease
- Tags
- OMIM
- 606559
- Clinvar variants
- Variants in TRIM22
- Penetrance
- None
- Publications
- Panels with this gene
History Filter Activity
Added Tag
Catherine Snow (Genomics England)Tag gene-checked tag was added to gene: TRIM22.
Removed Tag
Arina Puzriakova (Genomics England Curator)Tag for-review was removed from gene: TRIM22.
Added New Source, Status Update
Arina Puzriakova (Genomics England Curator)Source Expert Review Green was added to TRIM22. Rating Changed from Amber List (moderate evidence) to Green List (high evidence)
Entity classified by Genomics England curator
Arina Puzriakova (Genomics England Curator)Gene: trim22 has been classified as Amber List (Moderate Evidence).
Added Tag
Arina Puzriakova (Genomics England Curator)Tag for-review tag was added to gene: TRIM22.
Entity classified by Genomics England curator
Ivone Leong (Genomics England Curator)Gene: trim22 has been classified as Green List (High Evidence).
Set Phenotypes
Ivone Leong (Genomics England Curator)Phenotypes for gene: TRIM22 were changed from Autoinflammatory Disorders; Granulomatous colitis; Diseases of Immune Dysregulation; TRIM22 to Autoinflammatory Disorders; Granulomatous colitis; Diseases of Immune Dysregulation; TRIM22; Inflammatory bowel disease
Set publications
Louise Daugherty (Genomics England Curator)Publications for gene TRIM22 were updated from 32048120; 32086639 to 26836588; 32086639; 32048120
Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes
Louise Daugherty (Genomics England Curator)gene: TRIM22 was added gene: TRIM22 was added to Primary immunodeficiency. Sources: IUIS Classification December 2019 Mode of inheritance for gene: TRIM22 was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: TRIM22 were set to 32048120; 32086639 Phenotypes for gene: TRIM22 were set to Autoinflammatory Disorders; Granulomatous colitis; Diseases of Immune Dysregulation; TRIM22