Adult solid tumours cancer susceptibility
Gene: FLCNEnsemblGeneIds (GRCh38): ENSG00000154803
EnsemblGeneIds (GRCh37): ENSG00000154803
OMIM: 607273, Gene2Phenotype
FLCN is in 12 panels
2 reviews
Ivone Leong (Genomics England Curator)
As discussed at the Genomics Cancer Panel Workshop, 16th July 2019: the group agreed that there is enough evidence to rate this gene greenCreated: 2 Aug 2019, 12:34 p.m. | Last Modified: 2 Aug 2019, 12:34 p.m.
Panel Version: 1.5
Clare Turnbull (Queen Mary University London)
Tumor Suppressor.Created: 5 Jul 2017, 12:19 p.m.
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Phenotypes
renal oncocytoma
Details
- Mode of Inheritance
- MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
- Sources
-
- NHS GMS
- Expert Review Green
- Expert list
- Phenotypes
-
- renal oncocytoma
- OMIM
- 607273
- Clinvar variants
- Variants in FLCN
- Penetrance
- Complete
- Panels with this gene
-
- Renal cancer pertinent cancer susceptibility
- Thoracic aortic aneurysm or dissection (GMS)
- Multiple monogenic benign skin tumours
- Adult solid tumours cancer susceptibility
- Familial pulmonary fibrosis
- Thoracic aortic aneurysm or dissection
- Inherited renal cancer
- Cystic kidney disease
- Ehlers Danlos syndrome with a likely monogenic cause
- Fetal anomalies
- Pneumothorax - familial
- Adult solid tumours for rare disease
History Filter Activity
Added New Source
Ivone Leong (Genomics England Curator)Source NHS GMS was added to FLCN.
Panel promoted to version 1.0
Louise Daugherty (Genomics England Curator)Clare Turnbull: Tumor Suppressor.
Added New Source
Ellen McDonagh (Genomics England Curator)FLCN was added to Adult solid tumourspanel. Source: Expert Review Green
Added New Source
Ellen McDonagh (Genomics England Curator)FLCN was added to Adult solid tumourspanel. Sources: Expert list
Created
Ellen McDonagh (Genomics England Curator)FLCN was created by ellenmcdonagh