Primary immunodeficiency or monogenic inflammatory bowel disease
Gene: LYZ

LYZ (lysozyme)
EnsemblGeneIds (GRCh38): ENSG00000090382
EnsemblGeneIds (GRCh37): ENSG00000090382
OMIM: 153450, Gene2Phenotype
LYZ is in 4 panels

2 reviews

Sophie Hambleton (Newcastle University)

Red List (low evidence)

Agree red rating
Created: 23 Oct 2019, 7:08 a.m. | Last Modified: 23 Oct 2019, 7:08 a.m.

Panel Version: 1.132

Created: 23 Oct 2019, 7:08 a.m.
Last Modified: 23 Oct 2019, 7:08 a.m.
Panel version: 1.132

Louise Daugherty (Genomics England Curator)

Red List (low evidence)

More relevant to Amyloidosis panel: already green there (https://panelapp.genomicsengland.co.uk/panels/502/) New gene added after review of potential new genes for PID by the Immunology Test Group. This gene was noted as being only theoretical for PID so was rated as Red by the group.
Created: 27 Sep 2019, 2:46 p.m. | Last Modified: 27 Sep 2019, 2:46 p.m.

Panel Version: 1.132

Created: 27 Sep 2019, 2:46 p.m.
Last Modified: 27 Sep 2019, 2:46 p.m.
Panel version: 1.132

Details

Mode of Inheritance

MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Sources

NHS GMS
Expert Review Red
London North GLH

Phenotypes

Amyloidosis, renal, 105200

OMIM

153450

Clinvar variants

Variants in LYZ

Penetrance

None

Panels with this gene

History Filter Activity

27 Sep 2019, Gel status: 1

Added New Source, Added New Source, Added New Source, Status Update

Louise Daugherty (Genomics England Curator)

Source London North GLH was added to LYZ. Source Expert Review Red was added to LYZ. Source NHS GMS was added to LYZ. Rating Changed from No List (delete) to Red List (low evidence)

27 Sep 2019, Gel status: 0

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Louise Daugherty (Genomics England Curator)

gene: LYZ was added gene: LYZ was added to Primary immunodeficiency. Sources: Mode of inheritance for gene: LYZ was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown Phenotypes for gene: LYZ were set to Amyloidosis, renal, 105200

Primary immunodeficiency or monogenic inflammatory bowel disease Gene: LYZ