Inherited renal cancer
Gene: FLCNEnsemblGeneIds (GRCh38): ENSG00000154803
EnsemblGeneIds (GRCh37): ENSG00000154803
OMIM: 607273, Gene2Phenotype
FLCN is in 12 panels
6 reviews
Arina Puzriakova (Genomics England Curator)
Comment on phenotypes: This gene is also associated with Colorectal cancer, somatic (MIM# 114500); Pneumothorax, primary spontaneous (MIM# 173600); Renal carcinoma, chromophobe, somatic (MIM# 144700)Created: 8 Mar 2021, 1:06 p.m. | Last Modified: 8 Mar 2021, 1:06 p.m.
Panel Version: 1.8
Ivone Leong (Genomics England Curator)
As discussed in the GMS Inherited Cancer Specialist Test Group webex call 31st Jan 2019: The Specialist Test Group agreed that there is enough evidence to rate this gene green.Created: 31 Jul 2019, 12:50 p.m. | Last Modified: 31 Jul 2019, 12:50 p.m.
Panel Version: 0.38
Lara Hawkes (Genomics England)
Rachel Robinson (Leeds Genetics Laboratory)
Sources: UKGTNCreated: 28 Dec 2018, 9:27 a.m.
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes
Renal carcinoma; Parotid oncocytomas; Neural tissue tumors; Lipomas; Angiolipomas
Publications
- PMID: 27899189
Variants in this GENE are reported as part of current diagnostic practice
Ellen McDonagh (Genomics England Curator)
Comment on list classification: Details checked against the Gene List for Reporting Germline Findings in Cancer Patients Version 1.5 document, for renal tumour type.Created: 26 Jul 2017, 12:14 p.m.
Clare Turnbull (Queen Mary University London)
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes
Renal
Details
- Mode of Inheritance
- MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
- Sources
-
- Expert Review Green
- Expert List
- Phenotypes
-
- Birt-Hogg-Dube syndrome, OMIM:135150
- Renal carcinoma, MONDO:0005206
- OMIM
- 607273
- Clinvar variants
- Variants in FLCN
- Penetrance
- Complete
- Publications
- Panels with this gene
-
- Pneumothorax - familial
- Adult solid tumours for rare disease
- Renal cancer pertinent cancer susceptibility
- Thoracic aortic aneurysm or dissection (GMS)
- Multiple monogenic benign skin tumours
- Cystic kidney disease
- Adult solid tumours cancer susceptibility
- Familial pulmonary fibrosis
- Thoracic aortic aneurysm or dissection
- Inherited renal cancer
- Ehlers Danlos syndrome with a likely monogenic cause
- Fetal anomalies
History Filter Activity
Set Phenotypes
Arina Puzriakova (Genomics England Curator)Phenotypes for gene: FLCN were changed from Renal carcinoma; Parotid oncocytomas; Neural tissue tumors; Lipomas; Angiolipomas to Birt-Hogg-Dube syndrome, OMIM:135150; Renal carcinoma, MONDO:0005206
Set publications
Rebecca Foulger (Genomics England curator)Publications for gene: FLCN were set to PMID: 27899189
Entity classified by Genomics England curator
Ivone Leong (Genomics England Curator)Gene: flcn has been classified as Green List (High Evidence).
Added New Source, Status Update
Ivone Leong (Genomics England Curator)Source Expert List was added to FLCN. Rating Changed from No List (delete) to Red List (low evidence)
Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes, Set penetrance
Rachel Robinson (Leeds Genetics Laboratory)gene: FLCN was added gene: FLCN was added to Inherited renal cancer. Sources: UKGTN Mode of inheritance for gene: FLCN was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Publications for gene: FLCN were set to PMID: 27899189 Phenotypes for gene: FLCN were set to Renal carcinoma; Parotid oncocytomas; Neural tissue tumors; Lipomas; Angiolipomas Penetrance for gene: FLCN were set to Complete Review for gene: FLCN was set to GREEN gene: FLCN was marked as current diagnostic