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Childhood solid tumours

Gene: DIS3L2

Green List (high evidence)
DIS3L2 (DIS3 like 3'-5' exoribonuclease 2)
EnsemblGeneIds (GRCh38): ENSG00000144535
EnsemblGeneIds (GRCh37): ENSG00000144535
OMIM: 614184, Gene2Phenotype
DIS3L2 is in 9 panels

4 reviews

Ivone Leong (Genomics England Curator)

Green List (high evidence)

As discussed at the Genomics Cancer Panel Workshop, 16th July 2019: the group agreed that there is enough evidence to rate this gene green.
Created: 2 Aug 2019, 11:03 a.m. | Last Modified: 2 Aug 2019, 11:03 a.m.
Panel Version: 1.27
Created: 2 Aug 2019, 11:03 a.m.
Last Modified: 2 Aug 2019, 11:03 a.m.
Panel version: 1.27

Lara Hawkes (Genomics England)

Green List (high evidence)

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Perlman syndrome, 267000

Created: 30 Jan 2019, 11:20 a.m.

Panel version: 1.23

Louise Daugherty (Genomics England Curator)

Comment on phenotypes: missing phenotype added to MIM ID
Created: 26 May 2017, 1:28 p.m.
Created: 26 May 2017, 1:28 p.m.

Panel version: 1.13

Richard Scott (Genomics England Curator)

Comment on list classification: Perlman syndrome causes growth disturbance and Wilms tumour
Created: 7 Mar 2016, 11:44 p.m.
Created: 7 Mar 2016, 11:44 p.m.

Panel version: 0.73

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • NHS GMS
  • Expert List
  • Expert Review Green
Phenotypes
  • Perlman syndrome, 267000
OMIM
614184
Clinvar variants
Variants in DIS3L2
Penetrance
Complete
Publications
Panels with this gene

History Filter Activity

2 Aug 2019, Gel status: 3

Added New Source, Set Phenotypes

Ivone Leong (Genomics England Curator)

Source NHS GMS was added to DIS3L2. Added phenotypes Perlman syndrome, 267000 for gene: DIS3L2

30 Jan 2019, Gel status: 3

Added New Source, Status Update

Ivone Leong (Genomics England Curator)

Source Expert List was added to DIS3L2. Rating Changed from Green List (high evidence) to Green List (high evidence)

26 May 2017, Gel status: 4

Set Phenotypes

Louise Daugherty (Genomics England Curator)

Phenotypes for DIS3L2 were set to Perlman syndrome, 267000

7 Mar 2016, Gel status: 4

Gene classified by Genomics England curator

Richard Scott (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

7 Mar 2016, Gel status: 4

Gene classified by Genomics England curator

Richard Scott (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

7 Mar 2016, Gel status: 0

Added New Source

Richard Scott (North Thames GMC/UCL)

DIS3L2 was added to Paediatric congenital malformation-dysmorphism-tumour syndromes panel. Sources: Expert list

7 Mar 2016, Gel status: 0

Created

Richard Scott (North Thames GMC/UCL)

DIS3L2 was created by Reviewer_03