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Childhood solid tumours

Gene: REST

Green List (high evidence)
REST (RE1 silencing transcription factor)
EnsemblGeneIds (GRCh38): ENSG00000084093
EnsemblGeneIds (GRCh37): ENSG00000084093
OMIM: 600571, Gene2Phenotype
REST is in 5 panels

3 reviews

Ivone Leong (Genomics England Curator)

Green List (high evidence)

As discussed at the Genomics Cancer Panel Workshop, 16th July 2019: the group agreed that there is enough evidence to rate this gene green
Created: 2 Aug 2019, 11:03 a.m. | Last Modified: 2 Aug 2019, 11:03 a.m.
Panel Version: 1.27
Created: 2 Aug 2019, 11:03 a.m.
Last Modified: 2 Aug 2019, 11:03 a.m.
Panel version: 1.27

Lara Hawkes (Genomics England)

Green List (high evidence)

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
616806

Created: 30 Jan 2019, 11:20 a.m.

Panel version: 1.23

Richard Scott (Genomics England Curator)

Comment on list classification: Familial Wilms tumour
Created: 7 Mar 2016, 11:51 p.m.
Created: 7 Mar 2016, 11:51 p.m.

Panel version: 0.84

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • NHS GMS
  • Expert List
  • Expert Review Green
Phenotypes
  • 616806
  • {Wilms tumor 6, susceptibility to} 616806
OMIM
600571
Clinvar variants
Variants in REST
Penetrance
Complete
Publications
Panels with this gene

History Filter Activity

2 Aug 2019, Gel status: 3

Added New Source, Set Phenotypes

Ivone Leong (Genomics England Curator)

Source NHS GMS was added to REST. Added phenotypes {Wilms tumor 6, susceptibility to} 616806 for gene: REST

30 Jan 2019, Gel status: 3

Added New Source, Status Update

Ivone Leong (Genomics England Curator)

Source Expert List was added to REST. Rating Changed from Green List (high evidence) to Green List (high evidence)

7 Mar 2016, Gel status: 4

Gene classified by Genomics England curator

Richard Scott (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

7 Mar 2016, Gel status: 4

Gene classified by Genomics England curator

Richard Scott (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

7 Mar 2016, Gel status: 0

Created

Richard Scott (North Thames GMC/UCL)

REST was created by Reviewer_03

7 Mar 2016, Gel status: 0

Added New Source

Richard Scott (North Thames GMC/UCL)

REST was added to Paediatric congenital malformation-dysmorphism-tumour syndromes panel. Sources: Expert list