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  3. TRIM28
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Childhood solid tumours

Gene: TRIM28

Green List (high evidence)
TRIM28 (tripartite motif containing 28)
EnsemblGeneIds (GRCh38): ENSG00000130726
EnsemblGeneIds (GRCh37): ENSG00000130726
OMIM: 601742, Gene2Phenotype
TRIM28 is in 2 panels

2 reviews

Shazia Mahamdallie (Great Ormond Street)

Green List (high evidence)

Inactivating TRIM28 mutations segregate with Wilms tumour and non-familial Wilms tumour in multiple studies - PMID 29912901 (N=5); PMID: 30694527 (N=9); PMID: 30885698 (N=15); LOH in tumour observed; TRIM28-mutated tumours associated with epithelial-type Wilms tumour histology; suggested maternal transmission.
Created: 12 Aug 2019, 8:16 a.m. | Last Modified: 12 Aug 2019, 8:16 a.m.
Panel Version: 1.32

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
Familial Wilms tumor; Wilms tumor

Publications

Created: 12 Aug 2019, 8:16 a.m.
Last Modified: 12 Aug 2019, 8:16 a.m.
Panel version: 1.32

Ivone Leong (Genomics England Curator)

Green List (high evidence)

TRIM28 is not associated with any phenotype on OMIM or Gene2Phenotype. There are >3 unrelated cases of patients who have Wilms tumour who are heterozygous for different variants in TRIM28. The variant segregated with the disease in the families and the tumour is homozygous for the variants. Therefore there is enough evidence for this gene to be green.
Created: 9 Aug 2019, 12:50 p.m. | Last Modified: 9 Aug 2019, 12:50 p.m.
Panel Version: 1.32

Publications

Created: 9 Aug 2019, 12:50 p.m.
Last Modified: 9 Aug 2019, 12:50 p.m.
Panel version: 1.32

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert list
  • Expert Review Green
Phenotypes
  • Familial Wilms tumor
  • Wilms tumour
Tags
gene-checked
OMIM
601742
Clinvar variants
Variants in TRIM28
Penetrance
None
Publications
Panels with this gene

History Filter Activity

7 May 2022, Gel status: 3

Added Tag

Eleanor Williams (Genomics England Curator)

Tag gene-checked tag was added to gene: TRIM28.

12 Aug 2019, Gel status: 3

Set mode of inheritance

Ivone Leong (Genomics England Curator)

Mode of inheritance for gene: TRIM28 was changed from MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

12 Aug 2019, Gel status: 3

Set Phenotypes

Ivone Leong (Genomics England Curator)

Phenotypes for gene: TRIM28 were changed from Wilms tumour to Familial Wilms tumor; Wilms tumour

9 Aug 2019, Gel status: 3

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Ivone Leong (Genomics England Curator)

gene: TRIM28 was added gene: TRIM28 was added to Tumour predisposition - childhood onset. Sources: Expert Review Green,Expert list Mode of inheritance for gene: TRIM28 was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown Publications for gene: TRIM28 were set to 29912901; 30694527; 30885698 Phenotypes for gene: TRIM28 were set to Wilms tumour