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Childhood solid tumours

Gene: WRN

Green List (high evidence)
WRN (Werner syndrome RecQ like helicase)
EnsemblGeneIds (GRCh38): ENSG00000165392
EnsemblGeneIds (GRCh37): ENSG00000165392
OMIM: 604611, Gene2Phenotype
WRN is in 17 panels

2 reviews

Ivone Leong (Genomics England Curator)

Green List (high evidence)

As discussed at the Genomics Cancer Panel Workshop, 16th July 2019: the group agreed that there is enough evidence to rate this gene green
Created: 2 Aug 2019, 11:03 a.m. | Last Modified: 2 Aug 2019, 11:03 a.m.
Panel Version: 1.27
Created: 2 Aug 2019, 11:03 a.m.
Last Modified: 2 Aug 2019, 11:03 a.m.
Panel version: 1.27

Lara Hawkes (Genomics England)

Green List (high evidence)

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Werner Syndrome

Created: 30 Jan 2019, 11:20 a.m.

Panel version: 1.23

History Filter Activity

2 Aug 2019, Gel status: 3

Added New Source, Set Phenotypes, Set publications

Ivone Leong (Genomics England Curator)

Source NHS GMS was added to WRN. Added phenotypes Werner Syndrome for gene: WRN Publications for gene WRN were changed from to 10440702

25 Jun 2019, Gel status: 3

Added New Source, Added New Source, Set mode of inheritance, Set Phenotypes, Status Update

Ivone Leong (Genomics England Curator)

Source Expert list was added to WRN. Source Expert Review Green was added to WRN. Mode of inheritance for gene WRN was changed from to BIALLELIC, autosomal or pseudoautosomal Added phenotypes Werner syndrome, 277700 for gene: WRN Rating Changed from Red List (low evidence) to Green List (high evidence)

30 Jan 2019, Gel status: 1

Created, Added New Source, Set mode of inheritance

Ivone Leong (Genomics England Curator)

gene: WRN was added gene: WRN was added to Tumour predisposition - childhood onset. Sources: Expert List Mode of inheritance for gene: WRN was set to