Childhood solid tumours
Gene: HRASEnsemblGeneIds (GRCh38): ENSG00000174775
EnsemblGeneIds (GRCh37): ENSG00000174775
OMIM: 190020, Gene2Phenotype
HRAS is in 30 panels
6 reviews
Ivone Leong (Genomics England Curator)
As discussed at the Genomics Cancer Panel Workshop, 16th July 2019: the group agreed that RASopathy associated genes associated with cancer will be included in this panel and that there is enough evidence to rate this gene green.Created: 2 Aug 2019, 11:03 a.m. | Last Modified: 2 Aug 2019, 11:03 a.m.
Panel Version: 1.27
Anna de Burca (Oxford University Hospitals NHS Foundation Trust)
Predisposition to cancer.Created: 2 Aug 2019, 11:03 a.m. | Last Modified: 2 Aug 2019, 11:03 a.m.
Panel Version: 1.27
Publications
Lara Hawkes (Genomics England)
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Phenotypes
Costello syndrome
Richard Scott (Genomics England Curator)
Comment on list classification: Costello syndrome has an elevated risk of tumour in childhoodCreated: 7 Mar 2016, 11:32 p.m.
Richard Scott (North Thames GMC/UCL)
Costello syndrome has an elevated risk of tumour in childhoodCreated: 7 Mar 2016, 11:13 p.m.
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes
218040
Publications
Ellen Thomas (Genomics England Curator)
Comment on list classification: Rasopathy gene; not generally associated with malignancy.Created: 14 Feb 2016, 5:19 p.m.
Details
- Mode of Inheritance
- MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
- Sources
-
- NHS GMS
- Expert List
- Expert Review Green
- UKGTN
- Emory Genetics Laboratory
- Radboud University Medical Center, Nijmegen
- Phenotypes
-
- Costello syndrome
- Costello syndrome, 218040
- OMIM
- 190020
- Clinvar variants
- Variants in HRAS
- Penetrance
- Complete
- Publications
- Panels with this gene
-
- Hereditary neuropathy
- Hereditary neuropathy or pain disorder
- Intellectual disability
- Early onset or syndromic epilepsy
- DDG2P
- Pigmentary skin disorders
- Fetal hydrops
- Familial rhabdomyosarcoma
- Pneumothorax - familial
- Paediatric or syndromic cardiomyopathy
- Segmental overgrowth disorders - Deep sequencing
- Embryonal tumour of possible germline origin
- RASopathies
- IUGR and IGF abnormalities
- Hypertrophic cardiomyopathy
- Mosaic skin disorders - deep sequencing
- Childhood solid tumours cancer susceptibility
- Cytopenias and congenital anaemias
- Multiple monogenic benign skin tumours
- Sarcoma cancer susceptibility
- Monogenic short stature
- Sarcoma susceptibility
- Childhood solid tumours
- Arthrogryposis
- Adult solid tumours cancer susceptibility
- Congenital myopathy
- Primary lymphoedema
- Sarcoma of possible germline origin
- Fetal anomalies
- Neurological segmental overgrowth
History Filter Activity
Added New Source, Set mode of inheritance, Set Phenotypes, Set publications
Ivone Leong (Genomics England Curator)Source NHS GMS was added to HRAS. Mode of inheritance for gene HRAS was changed from MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown Added phenotypes Costello syndrome for gene: HRAS Publications for gene HRAS were changed from to 23875798
Added New Source, Status Update
Ivone Leong (Genomics England Curator)Source Expert List was added to HRAS. Rating Changed from Green List (high evidence) to Green List (high evidence)
Set Mode of Inheritance
Ellen McDonagh (Genomics England Curator)Mode of inheritance for HRAS was changed to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Set Phenotypes
Richard Scott (Genomics England Curator)Phenotypes for HRAS were set to Costello syndrome, 218040
Gene classified by Genomics England curator
Richard Scott (Genomics England Curator)This gene has been classified as Green List (High Evidence).
Gene classified by Genomics England curator
Ellen Thomas (Genomics England Curator)This gene has been classified as Red List (Low Evidence).
Added New Source
Eik Haraldsdottir (Genomics England)HRAS was added to Paediatric congenital malformation-dysmorphism-tumour syndromes panel. Sources: UKGTN
Added New Source
Eik Haraldsdottir (Genomics England)HRAS was added to Paediatric congenital malformation-dysmorphism-tumour syndromes panel. Sources: Emory Genetics Laboratory
Added New Source
Eik Haraldsdottir (Genomics England)HRAS was added to Paediatric congenital malformation-dysmorphism-tumour syndromes panel. Sources: Radboud University Medical Center, Nijmegen