Childhood solid tumours
Gene: WT1EnsemblGeneIds (GRCh38): ENSG00000184937
EnsemblGeneIds (GRCh37): ENSG00000184937
OMIM: 607102, Gene2Phenotype
WT1 is in 18 panels
3 reviews
Ivone Leong (Genomics England Curator)
As discussed at the Genomics Cancer Panel Workshop, 16th July 2019: the group agreed that there is enough evidence to rate this gene greenCreated: 2 Aug 2019, 11:03 a.m. | Last Modified: 2 Aug 2019, 11:03 a.m.
Panel Version: 1.27
Lara Hawkes (Genomics England)
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Phenotypes
Familial Wilms tumor
Richard Scott (North Thames GMC/UCL)
Some (most) missense mutations in zinc-finger domain are disease causing but rarely inherited, so de novo status is the best handle. PMID 15483024 is a good source.Created: 6 Aug 2015, 3:55 a.m.
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Publications
Mode of pathogenicity
loss-of-function (truncating variants and curated list of variants)
Details
- Mode of Inheritance
- MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
- Sources
-
- NHS GMS
- Expert List
- Expert Review Green
- Eligibility statement prior genetic testing
- UKGTN
- Emory Genetics Laboratory
- Illumina TruGenome Clinical Sequencing Services
- Radboud University Medical Center, Nijmegen
- Phenotypes
-
- Wagner Syndrome
- Frasier syndrome, 136680
- Nephrotic syndrome, type 4, 256370
- Denys-Drash syndrome, 194080
- Familial Wilms tumor
- Wilms Tumor 1
- Wilms Tumor
- Wilms tumour
- Meacham syndrome, 608978
- Mesothelioma, somatic, 156240
- Denys-Drash Syndrome
- Wilms tumor, type 1, 194070
- OMIM
- 607102
- Clinvar variants
- Variants in WT1
- Penetrance
- Complete
- Publications
- Panels with this gene
-
- Cytopenias and congenital anaemias
- Unexplained kidney failure in young people
- DDG2P
- Sarcoma cancer susceptibility
- Intellectual disability
- Differences in sex development
- Familial rhabdomyosarcoma
- Wilms tumour with features suggestive of predisposition
- Adult solid tumours for rare disease
- Retinal disorders
- Sarcoma susceptibility
- Childhood solid tumours
- Adult solid tumours cancer susceptibility
- Structural eye disease
- Fetal anomalies
- Proteinuric renal disease
- Glaucoma (developmental)
- Childhood solid tumours cancer susceptibility
History Filter Activity
Added New Source, Set mode of inheritance, Set Phenotypes, Set publications
Ivone Leong (Genomics England Curator)Source NHS GMS was added to WT1. Mode of inheritance for gene WT1 was changed from MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown Added phenotypes Familial Wilms tumor for gene: WT1 Publications for gene WT1 were changed from 15483024 to 23788249
Added New Source, Status Update
Ivone Leong (Genomics England Curator)Source Expert List was added to WT1. Rating Changed from Green List (high evidence) to Green List (high evidence)
Gene classified by Genomics England curator
Ellen Thomas (Genomics England Curator)This gene has been classified as Green List (High Evidence).
Set publications
Ellen Thomas (Genomics England Curator)Publications for WT1 were set to 15483024
Set Mode of Inheritance
Ellen Thomas (Genomics England Curator)Mode of inheritance for WT1 was changed to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Upload gene information
Ellen McDonagh (Genomics England Curator)WT1 was added to Paediatric congenital malformation-dysmorphism-tumour syndromes panel. Sources: Eligibility statement prior genetic testing,Radboud University Medical Center, Nijmegen,Illumina TruGenome Clinical Sequencing Services,Emory Genetics Laboratory,UKGTN
Set Phenotypes
Ellen McDonagh (Genomics England Curator)Phenotypes for gene WT1 were set to Wilms tumor, type 1, 194070; Denys-Drash syndrome, 194080; Nephrotic syndrome, type 4, 256370; Frasier syndrome, 136680; Meacham syndrome, 608978; Mesothelioma, somatic, 156240;Wagner Syndrome;Wilms Tumor;Wilms Tumor 1;Denys-Drash Syndrome; Wilms tumour
Set Mode of Inheritance
Eik Haraldsdottir (Genomics England)Model of inheritance for gene WT1 was changed to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Set Mode of Inheritance
Eik Haraldsdottir (Genomics England)Model of inheritance for gene WT1 was changed to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Set Mode of Inheritance
Eik Haraldsdottir (Genomics England)Model of inheritance for gene WT1 was changed to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Set Mode of Inheritance
Eik Haraldsdottir (Genomics England)Model of inheritance for gene WT1 was changed to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Added New Source
Eik Haraldsdottir (Genomics England)WT1 was added to Paediatric congenital malformation-dysmorphism-tumour syndromes panel. Sources: UKGTN
Added New Source
Eik Haraldsdottir (Genomics England)WT1 was added to Paediatric congenital malformation-dysmorphism-tumour syndromes panel. Sources: Emory Genetics Laboratory
Set Mode of Inheritance
Eik Haraldsdottir (Genomics England)Model of inheritance for gene WT1 was changed to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Set Mode of Inheritance
Eik Haraldsdottir (Genomics England)Model of inheritance for gene WT1 was changed to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Added New Source
Eik Haraldsdottir (Genomics England)WT1 was added to Paediatric congenital malformation-dysmorphism-tumour syndromes panel. Sources: Illumina TruGenome Clinical Sequencing Services
Added New Source
Eik Haraldsdottir (Genomics England)WT1 was added to Paediatric congenital malformation-dysmorphism-tumour syndromes panel. Sources: Radboud University Medical Center, Nijmegen