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Intellectual disability

Gene: EIF1AX

No list

EIF1AX (eukaryotic translation initiation factor 1A, X-linked)
EnsemblGeneIds (GRCh38): ENSG00000173674
EnsemblGeneIds (GRCh37): ENSG00000173674
OMIM: 300186, Gene2Phenotype
EIF1AX is in 1 panel

1 review

Julia Baptista (South East Genomic Laboratory Hub, Synnovis, King's College Hospital)

Green List (high evidence)

PMID: 42337333- describes four de novo hemizygous EIF1AX variants (comprising three missense and one splice variant) in four male individuals exhibiting variable neurodevelopmental disorders, including developmental and language delays, autistic behavioral problems, and facial dysmorphisms.
Functional studies using Drosophila models supported a LOF effect for (Lys64Glu) and p.(Asp90Gly) whilst no significant effect was seen for p.(Asn17Asp). Minigene analysis for the c.204 G > C showed aberrant mRNA splicing and a LOF allele.
Sources: Literature
Created: 4 Aug 2026, 1:33 p.m.

Mode of inheritance
X-LINKED: hemizygous mutation in males, biallelic mutations in females

Phenotypes
intellectual disability

Publications

Details

Mode of Inheritance
X-LINKED: hemizygous mutation in males, biallelic mutations in females
Sources
Phenotypes
  • intellectual disability
OMIM
300186
Clinvar variants
Variants in EIF1AX
Penetrance
None
Publications
Panels with this gene

History Filter Activity

4 Aug 2026, Gel status: 0

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Julia Baptista (South East Genomic Laboratory Hub, Synnovis, King's College Hospital)

gene: EIF1AX was added gene: EIF1AX was added to Intellectual disability. Sources: Literature Mode of inheritance for gene: EIF1AX was set to X-LINKED: hemizygous mutation in males, biallelic mutations in females Publications for gene: EIF1AX were set to PMID: 42337333 Phenotypes for gene: EIF1AX were set to intellectual disability Review for gene: EIF1AX was set to GREEN