Genes in panel
Regions in panel
Prev Next

Intellectual disability

Gene: SPRY3

Red List (low evidence)

SPRY3 (sprouty RTK signaling antagonist 3)
EnsemblGeneIds (GRCh38): ENSG00000168939
EnsemblGeneIds (GRCh37): ENSG00000168939
OMIM: 300531, Gene2Phenotype
SPRY3 is in 1 panel

4 reviews

Eleanor Williams (Genomics England Curator)

Comment on mode of inheritance: This gene is in the pseudoautosomal region shared between chromosomes X and Y. The mode of inheritance should therefore be set to Biallelic or Monoallelic once more cases establish the inheritance pattern.
Created: 24 Nov 2019, 3:26 p.m. | Last Modified: 24 Nov 2019, 3:26 p.m.
Panel Version: 2.1106

Caroline Wright (Sanger)

Red List (low evidence)

Mode of inheritance
X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)

Rebecca Foulger (Genomics England curator)

Red List (low evidence)

Listed as 'candidate gene' in PMID:26350204 but no further ID evidence for inclusion on panel.
Created: 31 Oct 2017, 9:24 a.m.

Publications

Lu Raymond (university of cambridge )

Red List (low evidence)

Details

Mode of Inheritance
Unknown
Sources
  • Expert Review Red
OMIM
300531
Clinvar variants
Variants in SPRY3
Penetrance
Complete
Publications
Panels with this gene

History Filter Activity

24 Nov 2019, Gel status: 1

Set mode of inheritance

Eleanor Williams (Genomics England Curator)

Mode of inheritance for gene: SPRY3 was changed from X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males) to Unknown

12 Mar 2018, Gel status: 1

Panel promoted to version 2.0

Ellen McDonagh (Genomics England Curator)

12.03.2018: Due to major updates completed (Phase 1, 2 and 3), this panel was promoted to Version 2 in order to reflect the major updates since November 2017 which have resulted in reviews for 836 genes added by Genomics England Curators and the Clinical Team, 130 new Green genes added to the interpretation pipeline (from 751 to 881 Green genes), and the gene total has increased from 1879 to 1927.

29 Nov 2017, Gel status: 1

Set publications

Ellen McDonagh (Genomics England Curator)

Publications for gene SPRY3 was set to ['26350204']

13 Nov 2015, Gel status: 1

gel status update

GEL ()

The Gel status was updated for this whole panel

13 Nov 2015, Gel status: 2

gel status update

GEL ()

The Gel status was updated for this whole panel

13 Nov 2015, Gel status: 0

Created

Ellen McDonagh (Genomics England Curator)

SPRY3 was created by ellenmcdonagh

13 Nov 2015, Gel status: 0

Added New Source

Ellen McDonagh (Genomics England Curator)

SPRY3 was added to Intellectual disabilitypanel. Sources: Expert Review Red