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Intellectual disability

Gene: MIB1

Red List (low evidence)

MIB1 (mindbomb E3 ubiquitin protein ligase 1)
EnsemblGeneIds (GRCh38): ENSG00000101752
EnsemblGeneIds (GRCh37): ENSG00000101752
OMIM: 608677, Gene2Phenotype
MIB1 is in 4 panels

4 reviews

Louise Daugherty (Genomics England Curator)

Red List (low evidence)

Comment on publications: Candidate intellectual disability gene suggested by Grozeva et al, (2015) PMID: 26350204
Created: 28 Feb 2018, 8:21 p.m.
This is a candidate intellectual disability gene from Grozeva et al., (2015) PMID: 26350204, however no evidence to date has been found to support the association between variants of this gene and an observed intellectual disability phenotype.
This gene is also not currently a DD gene in Gene2Phenotype.
Created: 28 Feb 2018, 8:20 p.m.

Ellen McDonagh (Genomics England Curator)

Red List (low evidence)

This is a candidate ID gene in PMID 26350204 (Grozeva et al, 2015) and in Gilissen et al, 2014 PMID: 24896178, though a literature search doesn't find any evidence for ID cases, the gene is not within Gene2Phenotype.
Created: 12 Dec 2017, 5:30 p.m.

Publications

Caroline Wright (Sanger)

Red List (low evidence)

Lu Raymond (university of cambridge )

Red List (low evidence)

Details

History Filter Activity

12 Mar 2018, Gel status: 1

Panel promoted to version 2.0

Ellen McDonagh (Genomics England Curator)

12.03.2018: Due to major updates completed (Phase 1, 2 and 3), this panel was promoted to Version 2 in order to reflect the major updates since November 2017 which have resulted in reviews for 836 genes added by Genomics England Curators and the Clinical Team, 130 new Green genes added to the interpretation pipeline (from 751 to 881 Green genes), and the gene total has increased from 1879 to 1927.

12 Mar 2018, Gel status: 1

Set publications

Ellen McDonagh (Genomics England Curator)

Publications for gene MIB1 was set to ['26350204']

20 Dec 2017, Gel status: 1

Set publications

Louise Daugherty (Genomics England Curator)

Publications for MIB1 were set to 26350204; 24896178

12 Dec 2017, Gel status: 1

Gene classified by Genomics England curator

Ellen McDonagh (Genomics England Curator)

This gene has been classified as Red List (Low Evidence).

13 Nov 2015, Gel status: 1

gel status update

GEL ()

The Gel status was updated for this whole panel

13 Nov 2015, Gel status: 2

gel status update

GEL ()

The Gel status was updated for this whole panel

13 Nov 2015, Gel status: 0

Added New Source

Ellen McDonagh (Genomics England Curator)

MIB1 was added to Intellectual disabilitypanel. Sources: Expert Review Red

13 Nov 2015, Gel status: 0

Created

Ellen McDonagh (Genomics England Curator)

MIB1 was created by ellenmcdonagh