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Intellectual disability

Gene: ALG11

Green List (high evidence)

ALG11 (ALG11, alpha-1,2-mannosyltransferase)
EnsemblGeneIds (GRCh38): ENSG00000253710
EnsemblGeneIds (GRCh37): ENSG00000253710
OMIM: 613666, Gene2Phenotype
ALG11 is in 9 panels

5 reviews

Louise Daugherty (Genomics England Curator)

As a result of watchlist tag audit the watchlist tag was removed from ALG11- this is now a green gene with sufficient evidence/review
Created: 13 Jan 2020, 3:32 p.m. | Last Modified: 13 Jan 2020, 3:32 p.m.
Panel Version: 3.0

Caroline Wright (Sanger)

I don't know

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
ALG11-CDG (CDG-IP)

Publications

  • 0

Ellen McDonagh (Genomics England Curator)

Comment on list classification: This gene was promoted from red to green due to internal discussion - is green on the Undiagnosed metabolic disorders gene panel (version 1.31).
Created: 31 Mar 2017, 10:49 p.m.
Comment on list classification: This gene was promoted from red to green due to internal discussion - is green on the Undiagnosed metabolic disorders gene panel (version 1.31).
Created: 31 Mar 2017, 10:48 p.m.

Lu Raymond (university of cambridge )

I don't know

Richard Scott (Genomics England Curator)

Comment on list classification: Insufficient evidence to date
Created: 29 Jan 2016, 5:31 p.m.

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
Phenotypes
  • Congenital disorder of glycosylation, type Ip 613661
  • ALG11-CDG (CDG-IP)
OMIM
613666
Clinvar variants
Variants in ALG11
Penetrance
Complete
Publications
Panels with this gene

History Filter Activity

13 Jan 2020, Gel status: 3

Removed Tag

Louise Daugherty (Genomics England Curator)

Tag watchlist was removed from gene: ALG11.

28 Sep 2018, Gel status: 4

Added New Source

Louise Daugherty (Genomics England Curator)

Source Victorian Clinical Genetics Services was added to ALG11.

12 Mar 2018, Gel status: 3

Panel promoted to version 2.0

Ellen McDonagh (Genomics England Curator)

12.03.2018: Due to major updates completed (Phase 1, 2 and 3), this panel was promoted to Version 2 in order to reflect the major updates since November 2017 which have resulted in reviews for 836 genes added by Genomics England Curators and the Clinical Team, 130 new Green genes added to the interpretation pipeline (from 751 to 881 Green genes), and the gene total has increased from 1879 to 1927.

31 Mar 2017, Gel status: 4

Gene classified by Genomics England curator

Ellen McDonagh (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

31 Mar 2017, Gel status: 4

Gene classified by Genomics England curator

Ellen McDonagh (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

31 Mar 2017, Gel status: 1

Set publications

Ellen McDonagh (Genomics England Curator)

Publications for ALG11 were set to 27604308; 22213132; 20080937

31 Mar 2017, Gel status: 1

Set publications

Ellen McDonagh (Genomics England Curator)

Publications for ALG11 were set to 27604308; 22213132; 20080937

15 Mar 2017, Gel status: 1

Set Phenotypes

Ellen McDonagh (Genomics England Curator)

Phenotypes for ALG11 were set to Congenital disorder of glycosylation, type Ip 613661;ALG11-CDG (CDG-IP)

15 Mar 2017, Gel status: 1

Set publications

Ellen McDonagh (Genomics England Curator)

Publications for ALG11 were set to 27604308; 22213132;20080937

15 Mar 2017, Gel status: 1

Set publications

Ellen McDonagh (Genomics England Curator)

Publications for ALG11 were set to 27604308; 22213132

15 Mar 2017, Gel status: 1

Set publications

Ellen McDonagh (Genomics England Curator)

Publications for ALG11 were set to 27604308; 22213132

29 Jan 2016, Gel status: 1

Gene classified by Genomics England curator

Richard Scott (Genomics England Curator)

This gene has been classified as Red List (Low Evidence).

29 Jan 2016, Gel status: 1

Gene classified by Genomics England curator

Richard Scott (Genomics England Curator)

This gene has been classified as Red List (Low Evidence).

29 Jan 2016, Gel status: 1

Gene classified by Genomics England curator

Richard Scott (Genomics England Curator)

This gene has been classified as Red List (Low Evidence).

13 Nov 2015, Gel status: 2

gel status update

GEL ()

The Gel status was updated for this whole panel

13 Nov 2015, Gel status: 2

gel status update

GEL ()

The Gel status was updated for this whole panel

13 Nov 2015, Gel status: 0

Added New Source

Ellen McDonagh (Genomics England Curator)

ALG11 was added to Intellectual disabilitypanel. Sources: Expert Review Amber

13 Nov 2015, Gel status: 0

Created

Ellen McDonagh (Genomics England Curator)

ALG11 was created by ellenmcdonagh