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Intellectual disability

Gene: MYH10

Red List (low evidence)

MYH10 (myosin heavy chain 10)
EnsemblGeneIds (GRCh38): ENSG00000133026
EnsemblGeneIds (GRCh37): ENSG00000133026
OMIM: 160776, Gene2Phenotype
MYH10 is in 5 panels

1 review

Louise Daugherty (Genomics England Curator)

Red List (low evidence)

Comment on mode of inheritance: This is a possible DD gene in Gene2Phenotype for MYH10-related Multiple congenital anomalies, where the MOI has been assigned
Created: 26 Feb 2018, 11:57 a.m.
Currently there is not enough evidence to support this gene being upgraded from the Red rating
Created: 26 Feb 2018, 11:55 a.m.
Comment on phenotypes: To date there is no OMIM gene-phenotype as this has not been confirmed since both of the reported cases (PMID:25003005, 24901346,25356899) the variants have been classified as a variant of unknown significance because its contribution to a complex neurologic phenotype has not been confirmed.
Created: 26 Feb 2018, 11:54 a.m.
Comment on publications: added publications to support the association to ID phenotype
Created: 26 Feb 2018, 11:50 a.m.

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Sources
  • Gene2Phenotype
Phenotypes
  • MYH10-related Multiple congenital anomalies, Intellectual disability
OMIM
160776
Clinvar variants
Variants in MYH10
Penetrance
None
Publications
Panels with this gene

History Filter Activity

12 Mar 2018, Gel status: 1

Panel promoted to version 2.0

Ellen McDonagh (Genomics England Curator)

12.03.2018: Due to major updates completed (Phase 1, 2 and 3), this panel was promoted to Version 2 in order to reflect the major updates since November 2017 which have resulted in reviews for 836 genes added by Genomics England Curators and the Clinical Team, 130 new Green genes added to the interpretation pipeline (from 751 to 881 Green genes), and the gene total has increased from 1879 to 1927.

12 Mar 2018, Gel status: 1

Added New Source

Ellen McDonagh (Genomics England Curator)

MYH10 was added to Intellectual disability panel. Sources: Gene2Phenotype

12 Mar 2018, Gel status: 1

Created

Ellen McDonagh (Genomics England Curator)

MYH10 was created by Ellen McDonagh