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Intellectual disability

Gene: CDK10

Green List (high evidence)

CDK10 (cyclin dependent kinase 10)
EnsemblGeneIds (GRCh38): ENSG00000185324
EnsemblGeneIds (GRCh37): ENSG00000185324
OMIM: 603464, Gene2Phenotype
CDK10 is in 3 panels

2 reviews

Louise Daugherty (Genomics England Curator)

Comment on list classification: Changed from Red to Green. Appropriate phenotype, sufficient cases and external expert review all support gene-disease association and relevance to this panel to rate gene as Green.
Created: 21 Feb 2019, 3:29 p.m.
Comment on publications: Added publication suggested by external reviewer to support gene-disease association, and upgrading of the gene to Green
Created: 21 Feb 2019, 3:25 p.m.

Konstantinos Varvagiannis (Other)

Green List (high evidence)

Biallelic pathogenic variants in CDK10 cause Al Kaissi syndrome (MIM 617694).

Windpassinger et al. (PMID: 28886341) report on 9 individuals from 5 consanguineous families.

The phenotype consisted of developmental delay, intellectual disability (all), growth retardation, spine malformations, and common facial features.

4 pathogenic variants are reported and each was found in the homozygous state in affected individuals [using NM_052988.4 as a reference : c.609-G>A, c.608+1G>A (2 families), c.139delG, as well as an intragenic deletion]. The splice site mutations were shown to behave as LoF (both resulted in frameshift or internal truncation, significantly reduced expression levels and reduced CDK10 activity was demonstrated for 1 variant).

Cdk10-knockout in mice reproduced - at least partly - the human phenotypes. Additional functional studies suggest ciliary defects might contribute to the phenotype.

CDK10 is included in the DD panel of G2P associated with Severe Growth Retardation, Spine Malformations, and Developmental Delays (ID among the assigned phenotypes).

This gene is included in gene panels for ID offered by diagnostic laboratories (incl. Radboudumc).

As a result CDK10 should be considered for upgrade to green.
Created: 20 Dec 2018, 11:09 a.m.

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Al Kaissi syndrome (MIM 617694)


Variants in this GENE are reported as part of current diagnostic practice


Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
  • Expert Review Green
  • Victorian Clinical Genetics Services
  • Al Kaissi syndrome, 617694
  • intellectual disability
Clinvar variants
Variants in CDK10
Panels with this gene

History Filter Activity

21 Feb 2019, Gel status: 3

Entity classified by Genomics England curator

Louise Daugherty (Genomics England Curator)

Gene: cdk10 has been classified as Green List (High Evidence).

21 Feb 2019, Gel status: 1

Set mode of inheritance

Louise Daugherty (Genomics England Curator)

Mode of inheritance for gene: CDK10 was changed from to BIALLELIC, autosomal or pseudoautosomal

21 Feb 2019, Gel status: 1

Set publications

Louise Daugherty (Genomics England Curator)

Publications for gene: CDK10 were set to

21 Feb 2019, Gel status: 1

Set Phenotypes

Louise Daugherty (Genomics England Curator)

Phenotypes for gene: CDK10 were changed from to Al Kaissi syndrome, 617694; intellectual disability

28 Sep 2018, Gel status: 1

Created, Added New Source, Set mode of inheritance

Louise Daugherty (Genomics England Curator)

gene: CDK10 was added gene: CDK10 was added to Intellectual disability. Sources: Victorian Clinical Genetics Services Mode of inheritance for gene: CDK10 was set to