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Intellectual disability

Gene: FBXO25

Red List (low evidence)

FBXO25 (F-box protein 25)
EnsemblGeneIds (GRCh38): ENSG00000147364
EnsemblGeneIds (GRCh37): ENSG00000147364
OMIM: 609098, Gene2Phenotype
FBXO25 is in 2 panels

3 reviews

Ellen McDonagh (Genomics England Curator)

Red List (low evidence)

Not associated with a disease in OMIM. It is a possible DD gene for the F-Box only protein 25. PMID: 16278047 - describes characterisation of this gene, which was disrupted by translocation in a case with mental retardation and epilepsy. It is expressed in the brain. There does not seem to be enough evidence at this time to make this gene green.
Created: 13 Dec 2017, 9:46 p.m.

Phenotypes
Expression in brain

Publications

Caroline Wright (Sanger)

Red List (low evidence)

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
F-BOX ONLY PROTEIN 25; FBXO25

Publications

  • 0

Lu Raymond (university of cambridge )

Red List (low evidence)

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Red
Phenotypes
  • Expression in brain
OMIM
609098
Clinvar variants
Variants in FBXO25
Penetrance
Complete
Publications
Panels with this gene

History Filter Activity

12 Mar 2018, Gel status: 1

Panel promoted to version 2.0

Ellen McDonagh (Genomics England Curator)

12.03.2018: Due to major updates completed (Phase 1, 2 and 3), this panel was promoted to Version 2 in order to reflect the major updates since November 2017 which have resulted in reviews for 836 genes added by Genomics England Curators and the Clinical Team, 130 new Green genes added to the interpretation pipeline (from 751 to 881 Green genes), and the gene total has increased from 1879 to 1927.

5 Jan 2018, Gel status: 1

Set publications

Ellen McDonagh (Genomics England Curator)

Publications for gene FBXO25 was set to ['16278047']

13 Nov 2015, Gel status: 1

gel status update

GEL ()

The Gel status was updated for this whole panel

13 Nov 2015, Gel status: 2

gel status update

GEL ()

The Gel status was updated for this whole panel

13 Nov 2015, Gel status: 0

Added New Source

Ellen McDonagh (Genomics England Curator)

FBXO25 was added to Intellectual disabilitypanel. Sources: Expert Review Red

13 Nov 2015, Gel status: 0

Created

Ellen McDonagh (Genomics England Curator)

FBXO25 was created by ellenmcdonagh