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Intellectual disability

Gene: MRE11

Red List (low evidence)
MRE11 (MRE11 homolog, double strand break repair nuclease)
EnsemblGeneIds (GRCh38): ENSG00000020922
EnsemblGeneIds (GRCh37): ENSG00000020922
OMIM: 600814, Gene2Phenotype
MRE11 is in 17 panels

5 reviews

Caroline Wright (Sanger)

I don't know

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
ATAXIA TELANGIECTASIA-LIKE DISORDER

Publications

Created: 5 Nov 2017, 2:42 a.m.

Panel version: 0

BRIDGE consortium (NIHRBR-RD)

Green List (high evidence)

This is a pertinent gene from the NIHR BioResource - Rare Diseases Study (NIHRBR-RD) BRIDGE Study : SPEED (Specialist Pathology: Evaluating Exomes in Diagnostics) which covers epilepsies, movement and microcephaly disorders, this gene is on the SPEED_NEURO_20170705 gene list. Evidences used for SPEED NEURO gene list: in_ddg2p_20141118_conf;in_ddg2p_20141118_conf;in_ddg2p_201507;in_ddg2p_201507_conf;in_omim_20150205_movement . Main mutation mechanism : Loss of function
Created: 27 Jul 2017, 7:38 p.m.
Evidences key, gene present in following gene lists and main mutation mechanism : ddg2p_20141118; ddg2p_20141118_conf; ddg2p_201507; ddg2p_201507_conf; omim_20150205_movement; GEL_ID_red_20160217; neuro_20160418_strict; Loss of function. This is a pertinent gene from the BRIDGE Study : SPEED (Specialist Pathology: Evaluating Exomes in Diagnostics) which covers epilepsies, movement and microcephaly disorders, this gene comes from the SPEED_NEURO_v3.0_20170404 gene list. The following experts from the BRIDGE consortium NIHRBR-RD contributed to this panel: - Professor F. Lucy Raymond, Cambridge Institute for Medical Research, University of Cambridge - Manju Kurian, Paediatric neurologist, Great Ormond Street Hosptial - Keren Carss, NIHR BioResource - Rare Diseases, Cambridge University Hospitals NHS Foundation Trust - Alba Sanchis-Juan, NIHR BioResource - Rare Diseases, Cambridge University Hospitals NHS Foundation Trust - Marie Erwood NIHR BioResource - Rare Diseases, Cambridge University Hospitals NHS Foundation Trust - Louise Daugherty, NIHR BioResource - Rare Diseases, Cambridge University Hospitals NHS Foundation Trust
Created: 19 Jul 2017, 12:52 p.m.

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Publications

Created: 2 Aug 2017, 8:36 p.m.

Panel version: 1.354

Louise Daugherty (Genomics England Curator)

Red List (low evidence)

Nomenclature history profile of this gene (from correspondence with HGNC) : a change was made in the 1990s of the gene symbol MRE11 to MRE11A which left a withdrawn MRE11 gene symbol even though this was really just a rename. Then, recently, MRE11A was named back to MRE11after MRE11B turned out to be a pseudogene and was renamed to MRE11P1. HGNC will now delete the MRE11 withdrawn symbol so that this confusion will not occur again. There is now only one MRE11 record, with HGNC:7230. Variants of this gene have been confirmed to cause Ataxia-telangiectasia-like disorder, an autosomal recessive movement disorder characterized clinically by progressive cerebellar degeneration resulting in ataxia and oculomotor apraxia (PMID: 10612394, 11371508, 22863007, 15269180). However, Matsumoto Y et al., (2011) PMID: 21227757 found that two unrelated patients with MRE11A mutations and Nijmegen breakage syndrome-like severe microcephaly. Noting that MRE11 and NBN function together as components of a MRE11-RAD50-NBN protein complex, deficiency of either protein did not result in the same clinical features. Mutations in the NBN gene underlie Nijmegen breakage syndrome (NBS), a chromosomal instability syndrome characterized by microcephaly, bird-like faces, growth and mental retardation, and cellular radiosensitivity. Additionally, mutations in the MRE11A gene are known to lead to an ataxia-telangiectasia-like disorder (ATLD), a late-onset, slowly progressive variant of ataxia-telangiectasia without microcephaly. In their study Matsumoto Y et al., (2011) PMID: 21227757 describe two unrelated patients with NBS-like severe microcephaly (head circumference -10.2 SD and -12.8 SD) with mutations just in the MRE11A gene. Both patients were compound heterozygotes for a truncating or missense mutation and carried a translationally silent mutation. The truncating and missense mutations were assumed to be functionally debilitating. The translationally silent mutation common to both patients had an effect on splicing efficiency resulting in reduced but normal MRE11 protein. Comment on phenotypes: phenotype from PMID: 21227757. Comment on list classification: two cases with ID for Nijmegen breakage syndrome-like severe microcephaly, both cases had speech and learning difficulties, however there are other reports with pathogenic variants in patients with conditions such as Hereditary cancer-predisposing syndrome and Microcephaly, normal intelligence and immunodeficiency. Comment on publications: added publication to support association to Nijmegen breakage syndrome-like severe microcephaly.Flagged for clinical team to review - could potentially be Amber based on PMID: 21227757 (2011). However, only a single published study to date and since then (see clinvar) there are many more cases but with other associated conditions with : Microcephaly, normal intelligence and immunodeficiency (ID is normal) and is linked to Hereditary cancer-predisposing syndrome. Clinical team review confirmed this gene should remain rated as Red on the ID panel. HB noted that although ID can be a feature there are usually other clues re DNA repair disorders. Gene added as Amber to Cockayne and Xeroderna Pigmentosum-like disorder and New gene for Primary Microcephaly - Microcephalic Dwarfism Spectrum panels.
Created: 12 Mar 2018, 9:47 a.m.
Nomenclature history profile of this gene (from correspondence with HGNC) : a change was made in the 1990s of the gene symbol MRE11 to MRE11A which left a withdrawn MRE11 gene symbol even though this was really just a rename. Then, recently, MRE11A was named back to MRE11after MRE11B turned out to be a pseudogene and was renamed to MRE11P1. HGNC will now delete the MRE11~withdrawn symbol so that this confusion will not occur again. There is now only one MRE11 record, with HGNC:7230.
Created: 20 Jul 2017, 2:56 p.m.
added new-gene-name tag. New approved HGNC gene symbol is MRE11.
Created: 20 Jul 2017, 2:56 p.m.

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Nijmegen breakage syndrome-like severe microcephaly, Intellectual disability

Publications

Created: 20 Jul 2017, 2:56 p.m.

Panel version: 1.677

Lu Raymond (university of cambridge )

I don't know

Created: 23 Feb 2016, 10:08 a.m.

Panel version: 0.306

Richard Scott (Genomics England Curator)

Comment on list classification: Not an ID phenotype
Created: 7 Feb 2016, 11:30 p.m.
Created: 7 Feb 2016, 11:30 p.m.

Panel version: 0.188

History Filter Activity

12 Mar 2018, Gel status: 1

Panel promoted to version 2.0

Ellen McDonagh (Genomics England Curator)

12.03.2018: Due to major updates completed (Phase 1, 2 and 3), this panel was promoted to Version 2 in order to reflect the major updates since November 2017 which have resulted in reviews for 836 genes added by Genomics England Curators and the Clinical Team, 130 new Green genes added to the interpretation pipeline (from 751 to 881 Green genes), and the gene total has increased from 1879 to 1927.

12 Mar 2018, Gel status: 1

Set publications

Ellen McDonagh (Genomics England Curator)

Publications for gene MRE11 was set to ['21227757']

5 Nov 2017, Gel status: 1

Changed Gene Name

GEL ()

MRE11A was changed to MRE11

5 Nov 2017, Gel status: 1

Removed Tag

GEL ()

new-gene-name was removed from MRE11A. Panel: Intellectual disability

7 Feb 2016, Gel status: 1

Gene classified by Genomics England curator

Richard Scott (Genomics England Curator)

This gene has been classified as Red List (Low Evidence).

7 Feb 2016, Gel status: 1

Gene classified by Genomics England curator

Richard Scott (Genomics England Curator)

This gene has been classified as Red List (Low Evidence).

13 Nov 2015, Gel status: 2

gel status update

GEL ()

The Gel status was updated for this whole panel

13 Nov 2015, Gel status: 2

gel status update

GEL ()

The Gel status was updated for this whole panel

13 Nov 2015, Gel status: 0

Created

Ellen McDonagh (Genomics England Curator)

MRE11A was created by ellenmcdonagh

13 Nov 2015, Gel status: 0

Added New Source

Ellen McDonagh (Genomics England Curator)

MRE11A was added to Intellectual disabilitypanel. Sources: Expert Review Amber