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COVID-19 research

Gene: ATG16L1

Amber List (moderate evidence)
ATG16L1 (autophagy related 16 like 1)
EnsemblGeneIds (GRCh38): ENSG00000085978
EnsemblGeneIds (GRCh37): ENSG00000085978
OMIM: 610767, Gene2Phenotype
ATG16L1 is in 2 panels

2 reviews

Alison Coffey (Illumina Clinical Services Laboratory, Illumina Inc.)

I don't know

Evidence Summary from Illumina curation team: The ATG16L gene encodes a core autophagy protein which forms a complex with ATG5 and ATG12 that is important for autophagophore elongation (Lavoie et al. 2019). Autophagy plays a key antiviral role in various human infections by modulating different aspects of the immune response (Reviewed Tao et al. 2020; Ahmed et al. 2018). The ATG16L complex is also targeted by some viruses to enhance infection. The Zika virus protease, targets ATG16L, dramatically depleting its levels during Zika virus infection (Hill et al. 2018). Conversely, Hepatitis B virus (HBV), an enveloped pararetrovirus, stimulates autophagy to favor its production. In vitro, RNA interference-mediated silencing of Atg16L1 interfered with viral core/nucleocapsid (NC) formation and stability, strongly diminishing virus replication (Fletcher et al. 2018).
Created: 28 May 2020, 3:12 p.m. | Last Modified: 28 May 2020, 3:12 p.m.
Panel Version: 0.347

Publications

Created: 28 May 2020, 2:32 p.m.
Last Modified: 28 May 2020, 2:32 p.m.
Panel version: 0.347

Rebecca Foulger (Genomics England curator)

Comment on list classification: Gene was originally added to panel as Red following initial triage by Illumina curation team (Alison Coffey and Julie Taylor). Updated rating to Amber to match revised Illumina review after literature curation.
Created: 28 May 2020, 2:33 p.m. | Last Modified: 28 May 2020, 2:33 p.m.
Panel Version: 0.342
Identified through an OMIM search for potential viral susceptibility genes, and subsequently triaged/reviewed by Illumina curation team.
Created: 28 May 2020, 12:36 p.m. | Last Modified: 28 May 2020, 12:36 p.m.
Panel Version: 0.336
Created: 28 May 2020, 12:36 p.m.
Last Modified: 28 May 2020, 12:36 p.m.
Panel version: 0.336

Details

Mode of Inheritance
Unknown
Sources
  • Expert Review Amber
  • Expert list
  • OMIM
OMIM
610767
Clinvar variants
Variants in ATG16L1
Penetrance
None
Publications
Panels with this gene

History Filter Activity

28 May 2020, Gel status: 2

Set publications

Rebecca Foulger (Genomics England curator)

Publications for gene: ATG16L1 were set to

28 May 2020, Gel status: 2

Entity classified by Genomics England curator

Rebecca Foulger (Genomics England curator)

Gene: atg16l1 has been classified as Amber List (Moderate Evidence).

28 May 2020, Gel status: 1

Entity classified by Genomics England curator

Rebecca Foulger (Genomics England curator)

Gene: atg16l1 has been classified as Red List (Low Evidence).

28 May 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance

Rebecca Foulger (Genomics England curator)

gene: ATG16L1 was added gene: ATG16L1 was added to COVID-19 research. Sources: Expert Review Red,OMIM,Expert list Mode of inheritance for gene: ATG16L1 was set to Unknown