COVID-19 research

Gene: CASP1

Green List (high evidence)

PMID: 19362023 is a mouse study model where KO Casp1 mice were more susceptible than WT mice after infection with infleunza A. This increased morbidity was associated with decreased neutrophil and monocyte recruitment and reduced cytokine and chemokine production.

PMID: 32303424. CASP1 were Hub proteins in the regulating network of cytokine secretion suggesting that it is important in ACE2-associated inflammatory response in lungs.

Binding of COVID-19 to Toll-like receptors causes release of pro-IL-1b, which requires CASP1 to cleave it in order for inflammasome activation and production of mature IL-1b (mediator of lung inflammation, fever and fibrosis). Suppressing the IL-1 family and IL-6 has been shown to have a therapeutic effect in viral infections (PMID: 32171193). CASP1 has been suggested to be a potential target for treatment (PMID: 22432004).

Created: 28 May 2020, 12:51 p.m. | Last Modified: 28 May 2020, 12:51 p.m.

Panel Version: 0.336

Identified through an OMIM search for potential viral susceptibility genes, and subsequently triaged/reviewed by Illumina curation team.

Created: 28 May 2020, 12:36 p.m. | Last Modified: 28 May 2020, 12:36 p.m.

Panel Version: 0.336