COVID-19 research
Gene: HYOU1

HYOU1 (hypoxia up-regulated 1)
EnsemblGeneIds (GRCh38): ENSG00000149428
EnsemblGeneIds (GRCh37): ENSG00000149428
OMIM: 601746, Gene2Phenotype
HYOU1 is in 2 panels

2 reviews

Louise Daugherty (Genomics England Curator)

OriginaI Metadata from IUIS classification table (February, 2018) downloaded 20180614. IUIS Genetic defect (original gene symbol in IUIS download): HYOU1 .PanelApp HGNC gene symbol check: HYOU1 . IUIS Disease: HYOU1 deficiency . IUIS Inheritance: AR .T cells: N/A, .B cells: N/A, .IUIS Other affected cells: N. IUIS Associated features: Hypoglycemia, inflammatory complications. IUIS Major category: Congenital defects of phagocyte number or function. IUIS Subcategory: Congenital Neutropenias
Created: 6 Jul 2018, 12:27 p.m.

Created: 6 Jul 2018, 12:27 p.m.

Panel version: Imported from Primary immunodeficiency panel version 0.1567

Sophie Hambleton (Newcastle University)

Red List (low evidence)

no publications to support link to primary immunodeficiency
Created: 29 Jun 2018, 9:14 p.m.

Created: 29 Jun 2018, 9:14 p.m.

Panel version: Imported from Primary immunodeficiency panel version 0.1371

Details

Mode of Inheritance

BIALLELIC, autosomal or pseudoautosomal

Sources

Expert Review Green
IUIS Classification December 2019
IUIS Classification February 2018
IUIS Classification December 2019
IUIS Classification February 2018

Phenotypes

Hypoglycemia, inflammatory complications
Congenital defects of phagocyte number or function

OMIM

601746

Clinvar variants

Variants in HYOU1

Penetrance

None

Publications

Panels with this gene

History Filter Activity

2 Apr 2020, Gel status: 3

Added New Source, Set Phenotypes, Status Update

Ellen McDonagh (Genomics England Curator)

Source Expert Review Green was added to HYOU1. Added phenotypes Hypoglycemia, inflammatory complications; Congenital defects of phagocyte number or function for gene: HYOU1 Rating Changed from Red List (low evidence) to Green List (high evidence)

1 Apr 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Ellen McDonagh (Genomics England Curator)

gene: HYOU1 was added gene: HYOU1 was added to Viral susceptibility. Sources: Expert Review Red,IUIS Classification February 2018,IUIS Classification December 2019 Mode of inheritance for gene: HYOU1 was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: HYOU1 were set to 32086639; 32048120 Phenotypes for gene: HYOU1 were set to Hypoglycemia, inflammatory complications; Congenital defects of phagocyte number or function

COVID-19 research Gene: HYOU1