COVID-19 research

Gene: IL9

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Evidence Summary from Illumina curation team: IL9 encodes interleukin 9, which is a stimulatory cytokine that regulates inflammatory immunity (Goswami and Kaplan 2011). It has been demonstrated that high levels of IL-9 are present in nasopharyngeal aspirate of infants with disease of the respiratory tract caused by the Human respiratory syncytial virus (RSV) (Semple et al. 2007). Studies conducted on mice showed that that the severity of lung pathology correlates with IL-9 cytokine production and that Th9 cells, which produce IL-9, play an important role in the development of airway eosinophilia and bronchial hyperresponsiveness (Dodd et al. 2009; Saeki et al. 2016). IL9 polymorphisms have also been linked to sex-restricted differences in lung function, allergen sensitization, IgE levels, and the severity of respiratory syncytial virus infection (Schuurhof et al. 2010; Aschard et al. 2009).

Created: 28 May 2020, 3:12 p.m. | Last Modified: 28 May 2020, 3:12 p.m.

Panel Version: 0.347

Publications

• 21368237
• 17940602
• 19915054
• 27297515
• 20503287
• 19536153

Identified through an OMIM search for potential viral susceptibility genes, and subsequently triaged/reviewed by Illumina curation team.

Created: 28 May 2020, 12:36 p.m. | Last Modified: 28 May 2020, 12:36 p.m.

Panel Version: 0.336