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COVID-19 research

Gene: ITPKC

Green List (high evidence)
ITPKC (inositol-trisphosphate 3-kinase C)
EnsemblGeneIds (GRCh38): ENSG00000086544
EnsemblGeneIds (GRCh37): ENSG00000086544
OMIM: 606476, Gene2Phenotype
ITPKC is in 1 panel

1 review

Catherine Snow (Genomics England)

I don't know

Adding ITPKC as a Kawasaki like disease in children linked to coronavirus.

Onouchi et al (PMID:18084290) identified a functional SNP in intron 1 of ITPKC (rs28493229) that was significantly associated with risk of Kawasaki disease and the formation of coronary artery aneurysms in both Japanese and U.S. children. But Chi et al. (2010) did not find a statistically significant association between the ITPKC gene SNP rs28493229 and Kawasaki disease or coronary artery lesions in Taiwanese children.
Sources: Literature, Research
Created: 5 May 2020, 4:17 p.m. | Last Modified: 5 May 2020, 4:22 p.m.
Panel Version: 0.198

Mode of inheritance
Unknown

Phenotypes
Kawasaki disease, susceptibility to, 611775

Publications

Created: 5 May 2020, 4:17 p.m.
Last Modified: 5 May 2020, 4:22 p.m.
Panel version: 0.197

Details

Mode of Inheritance
Unknown
Sources
  • Expert Review Green
  • Research
  • Literature
Phenotypes
  • Kawasaki disease, susceptibility to, 611775
OMIM
606476
Clinvar variants
Variants in ITPKC
Penetrance
None
Publications
Panels with this gene

History Filter Activity

13 May 2020, Gel status: 3

Set publications

Catherine Snow (Genomics England)

Publications for gene: ITPKC were set to 18084290; 20045869

13 May 2020, Gel status: 3

Entity classified by Genomics England curator

Catherine Snow (Genomics England)

Gene: itpkc has been classified as Green List (High Evidence).

5 May 2020, Gel status: 2

Entity classified by Genomics England curator

Catherine Snow (Genomics England)

Gene: itpkc has been classified as Amber List (Moderate Evidence).

5 May 2020, Gel status: 2

Entity classified by Genomics England curator

Catherine Snow (Genomics England)

Gene: itpkc has been classified as Amber List (Moderate Evidence).

5 May 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Catherine Snow (Genomics England)

gene: ITPKC was added gene: ITPKC was added to Viral susceptibility. Sources: Literature,Research Mode of inheritance for gene: ITPKC was set to Unknown Publications for gene: ITPKC were set to 18084290; 20045869 Phenotypes for gene: ITPKC were set to Kawasaki disease, susceptibility to, 611775 Review for gene: ITPKC was set to AMBER