COVID-19 research

Gene: MIS12

Red List (low evidence)

Using Collaborative Cross mouse genetic reference population, PMID 32348764 studied the genetic regulation of variation in antibody response to influenza A virus (IAV) infection. This enabled the identification of 23 quantitative trait loci (QTL) associated with variation in specific antibody isotypes across time points; this allowed a subset to be found that broadly affect the antibody response to IAV as well as other viruses. This gene is the equivalent human for the mouse gene that was classified as a candidate from one of the QTLs, based on the predicted variant consequences and haplotype-specific expression patterns (PMID 32348764 table 2).

Created: 27 May 2020, 10:50 a.m. | Last Modified: 27 May 2020, 10:50 a.m.

Panel Version: 0.332

Mode of inheritance
Unknown

Phenotypes
Influenza A Virus-Specific Antibody Responses

Publications

• 32348764