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COVID-19 research

Gene: PIK3CG

Green List (high evidence)
PIK3CG (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma)
EnsemblGeneIds (GRCh38): ENSG00000105851
EnsemblGeneIds (GRCh37): ENSG00000105851
OMIM: 601232, Gene2Phenotype
PIK3CG is in 2 panels

2 reviews

Sophie Hambleton (Newcastle University)

Green List (high evidence)

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Created: 7 May 2020, 2:08 p.m.
Last Modified: 7 May 2020, 2:08 p.m.
Panel version: 0.203

Ivone Leong (Genomics England Curator)

Green List (high evidence)

"Two individuals with complex immunological phenotypes reported and a mouse model. Sources: Literature
Zornitza Stark (Australian Genomics), 30 Apr 2020" - review copied from Primary immunodeficiency (Version 2.151).

"Comment on list classification: Gene added by Zornitza Stark (Australian Genomics) with recommended Green status based on provided evidence. There is enough evidence for this gene to be rated Green.
Ivone Leong (Genomics England Curator), 5 May 2020" - review copied from Primary immunodeficiency (Version 2.151).
Sources: Expert list
Created: 5 May 2020, 11:02 a.m.

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Immune dysregulation; HLH-like; childhood-onset antibody defects; cytopenias; T lymphocytic pneumonitis and colitis

Publications

Created: 5 May 2020, 11:02 a.m.

Panel version: 0.185

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • Expert list
Phenotypes
  • Immune dysregulation
  • HLH-like
  • childhood-onset antibody defects
  • cytopenias
  • T lymphocytic pneumonitis and colitis
OMIM
601232
Clinvar variants
Variants in PIK3CG
Penetrance
None
Publications
Panels with this gene

History Filter Activity

5 May 2020, Gel status: 3

Entity classified by Genomics England curator

Ivone Leong (Genomics England Curator)

Gene: pik3cg has been classified as Green List (High Evidence).

5 May 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Ivone Leong (Genomics England Curator)

gene: PIK3CG was added gene: PIK3CG was added to Viral susceptibility. Sources: Expert list Mode of inheritance for gene: PIK3CG was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: PIK3CG were set to 32001535; 31554793 Phenotypes for gene: PIK3CG were set to Immune dysregulation; HLH-like; childhood-onset antibody defects; cytopenias; T lymphocytic pneumonitis and colitis Review for gene: PIK3CG was set to GREEN