COVID-19 research

Gene: SOCS1

I don't know

PMID 12588885: In coxsackievirus-infected mice cardiac myocyte-specific transgenic expression of SOCS1 inhibited virus-induced signaling of JAK and STAT resulting in increased viral replication, cardiomyopathy, and mortality compared to controls. Inhibition of SOCS in cardiac myocytes increased myocyte resistance to the acute cardiac injury of enteroviral infection. It was suggested that inhibition of SOCS could augment the host-cell antiviral system and might prevent viral-mediated end-organ damage during the early stages of infection.
https://doi.org/10.1101/499988 reports: Genome-wide association study to identify loci that are associated with PID, and found evidence for the colocalization of—and interplay between—novel high-penetrance monogenic variants and common variants (at the PTPN2 and SOCS1 loci).

Sources: Literature

Created: 19 May 2020, 2:01 p.m. | Last Modified: 19 May 2020, 2:03 p.m.

Panel Version: 0.243

Mode of inheritance
Unknown

Phenotypes
primary immunodeficiency

Publications

• 12588885
• 12588885
• 18172216
• https://doi.org/10.1101/499988