COVID-19 research
Gene: STAT4

STAT4 (signal transducer and activator of transcription 4)
EnsemblGeneIds (GRCh38): ENSG00000138378
EnsemblGeneIds (GRCh37): ENSG00000138378
OMIM: 600558, Gene2Phenotype
STAT4 is in 2 panels

1 review

Louise Daugherty (Genomics England Curator)

Red List (low evidence)

Potential risk allele for SLE. New gene added after review of potential new genes for PID by the Immunology Test Group. This gene was noted as being only theoretical for PID so was rated as Red by the group.
Created: 27 Sep 2019, 2:54 p.m. | Last Modified: 27 Sep 2019, 2:54 p.m.

Panel Version: 1.132

Created: 27 Sep 2019, 2:54 p.m.
Last Modified: 27 Sep 2019, 2:54 p.m.
Panel version: Imported from Primary immunodeficiency panel version 1.132

Details

Mode of Inheritance

BOTH monoallelic and biallelic, autosomal or pseudoautosomal

Sources

London North GLH
NHS GMS
Expert Review Red
NHS GMS
Expert Review Red
London North GLH

Phenotypes

{Systemic lupus erythematosus, susceptibility to, 11}, 612253

OMIM

600558

Clinvar variants

Variants in STAT4

Penetrance

None

Panels with this gene

History Filter Activity

1 Apr 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Ellen McDonagh (Genomics England Curator)

gene: STAT4 was added gene: STAT4 was added to Viral susceptibility. Sources: Expert Review Red,NHS GMS,London North GLH Mode of inheritance for gene: STAT4 was set to BOTH monoallelic and biallelic, autosomal or pseudoautosomal Phenotypes for gene: STAT4 were set to {Systemic lupus erythematosus, susceptibility to, 11}, 612253

COVID-19 research Gene: STAT4