COVID-19 research

Gene: TNFSF4

Comment on list classification: Not associated with relevant phenotype in OMIM or in Gen2Phen.

Created: 28 May 2020, 5:07 p.m. | Last Modified: 28 May 2020, 5:07 p.m.

Panel Version: 0.362

TNFSF4 was identified through an OMIM search for potential viral susceptibility genes. Based on initial triage by Illumina (Tier 5 grouping).
Tumor necrosis factor (TNF) family cytokines function as prominent mediators of immune regulation and the inflammatory response. Most TNF family cytokines are expressed as type II transmembrane proteins, with homology confined to approximately 150 C-terminal residues. The TNF ligands interact with a parallel family of receptors (reviewed by Alison Coffey and team, Illumina).
TNFSF4 is a cell surface glycoprotein antigen that is expressed in T-cell leukemia virus type 1 (HTLV-1) infected human cells (PMID 7913952;8076595). Functional analysis showed that anti-TNFSF4 monoclonal antibody inhibited T-cell proliferation (PMID 11359859).
PMID 31725732: suggests that TNFSF4, one of the major causative cytokine factors in African swine fever virus pathogenesis, via inducing apoptosis.

Created: 28 May 2020, 5:06 p.m. | Last Modified: 28 May 2020, 5:57 p.m.

Panel Version: 0.365