- Panels
- COVID-19 research
- TRIM69
Genes in panel
- ABO 5
- ACD 4
- ACE2 7
- ACP5 5
- ACTB 3
- ADA 7
- ADA2 4
- ADAM17 6
- ADAR 4
- AICDA 6
- AIM2 2
- AIRE 4
- AK2 6
- ALPI 3
- AP1S3 4
- AP3B1 4
- AP3D1 2
- APOL1 2
- ARHGEF1 2
- ARPC1B 4
- ATM 4
- ATP6AP1 4
- B2M 4
- BACH2 4
- BCL10 2
- BCL11B 2
- BLK 1
- BLM 4
- BLNK 7
- BRCA1 0
- BRCA2 0
- BRIP1 2
- BTK 8
- C17orf62 2
- C1QA 4
- C1QB 5
- C1QC 4
- C1R 5
- C1S 5
- C2 4
- C3 5
- C4A 4
- C4B 4
- C5 4
- C6 4
- C7 4
- C8A 4
- C8B 4
- C8G 2
- C9 4
- CARD11 4
- CARD14 4
- CARD9 4
- CARMIL2 5
- CASP1 2
- CASP10 4
- CASP3 1
- CASP8 4
- CCBE1 4
- CCL2 3
- CCL5 4
- CCR2 2
- CD14 4
- CD19 6
- CD244 2
- CD247 6
- CD27 5
- CD3D 7
- CD3E 7
- CD3G 4
- CD40 4
- CD40LG 4
- CD46 4
- CD55 4
- CD59 4
- CD70 4
- CD79A 7
- CD79B 6
- CD81 2
- CD8A 2
- CDC42 2
- CDCA7 4
- CEBPE 5
- CFB 4
- CFD 4
- CFH 4
- CFHR1 2
- CFHR2 2
- CFHR3 2
- CFHR4 2
- CFHR5 4
- CFI 4
- CFP 4
- CFTR 3
- CHD7 4
- CIB1 4
- CIITA 5
- CLCN7 2
- CLPB 4
- COPA 4
- CORO1A 6
- CR2 4
- CSF2RA 4
- CSF2RB 4
- CSF3R 6
- CTC1 4
- CTLA4 6
- CTPS1 4
- CTSC 4
- CXCL8 2
- CXCR4 6
- CYBA 4
- CYBB 5
- DAG1 2
- DBR1 2
- DCLRE1B 4
- DCLRE1C 7
- DEF6 2
- DICER1 2
- DKC1 4
- DNAJC21 4
- DNASE1L3 4
- DNASE2 4
- DNMT3B 6
- DOCK2 4
- DOCK8 6
- EFL1 2
- EGFR 2
- ELANE 6
- EPG5 5
- ERBIN 2
- ERCC4 2
- ERCC6L2 4
- EXTL3 5
- F12 4
- FAAP24 2
- FADD 4
- FANCA 2
- FANCB 2
- FANCC 2
- FANCD2 2
- FANCE 2
- FANCF 1
- FANCG 2
- FANCI 1
- FANCL 2
- FANCM 1
- FAS 4
- FASLG 5
- FAT4 4
- FCGR2A 4
- FCGR3A 3
- FCHO1 2
- FCN3 2
- FERMT1 2
- FERMT3 4
- FOXN1 7
- FOXP3 4
- FPR1 2
- FPR2 4
- G6PC3 6
- G6PD 5
- GATA1 5
- GATA2 4
- GFI1 6
- GINS1 4
- HAVCR1 2
- HAVCR2 3
- HAX1 8
- HDAC6 2
- HELLS 4
- HLA-B 4
- HLA-DRB1 5
- HMOX1 2
- HPS1 4
- HPS4 4
- HPS6 4
- HTRA2 5
- HYOU1 2
- ICOS 6
- ICOSLG 3
- IFIH1 5
- IFITM3 4
- IFNA1 2
- IFNAR1 2
- IFNAR2 2
- IFNE 2
- IFNG 2
- IFNGR1 4
- IFNGR2 4
- IGHM 6
- IGKC 2
- IGLL1 6
- IKBKB 6
- IKBKG 4
- IKZF1 7
- IL10 4
- IL10RA 4
- IL10RB 4
- IL12B 4
- IL12RB1 4
- IL12RB2 2
- IL17A 4
- IL17F 2
- IL17RA 4
- IL17RC 4
- IL18BP 6
- IL1RN 5
- IL21 2
- IL21R 4
- IL23R 2
- IL2RA 4
- IL2RB 3
- IL2RG 7
- IL36RN 5
- IL6 2
- IL6R 5
- IL6ST 3
- IL7R 7
- INO80 4
- IRAK1 2
- IRAK4 4
- IRF1 2
- IRF2 2
- IRF2BP2 4
- IRF3 2
- IRF4 2
- IRF5 1
- IRF7 3
- IRF8 4
- IRF9 3
- ISG15 4
- ITCH 4
- ITGAV 2
- ITGB2 4
- ITGB3 2
- ITK 6
- ITPKC 1
- JAGN1 4
- JAK1 3
- JAK3 7
- KDM6A 2
- KIAA0319L 2
- KLF2 2
- KMT2A 2
- KMT2D 2
- LAMTOR2 4
- LAT 5
- LCK 4
- LIG1 3
- LIG4 7
- LPIN2 5
- LRBA 5
- LYST 5
- MAD2L2 2
- MAGT1 6
- MALT1 5
- MAP3K14 5
- MASP2 4
- MCM4 5
- MEFV 5
- MKL1 2
- MOGS 5
- MPO 5
- MS4A1 3
- MSH6 3
- MSN 4
- MTHFD1 5
- MVK 5
- MYD88 6
- MYO5B 5
- MYSM1 4
- NBAS 2
- NBN 5
- NCF1 5
- NCF2 5
- NCF4 6
- NCSTN 2
- NFAT5 3
- NFE2L2 2
- NFKB1 5
- NFKB2 7
- NFKBIA 5
- NHEJ1 8
- NHP2 5
- NLRC4 5
- NLRP1 4
- NLRP12 5
- NLRP3 5
- NOD2 5
- NOP10 3
- NOS2 2
- NSMCE3 4
- OAS1 4
- ORAI1 8
- OSTM1 2
- OTULIN 5
- PALB2 2
- PARN 5
- PAX1 2
- PEPD 4
- PGM3 5
- PIK3CD 8
- PIK3CG 2
- PIK3R1 8
- PLCG2 8
- PLEKHM1 2
- PMS2 3
- PNP 6
- POLA1 5
- POLD1 2
- POLD2 2
- POLE 3
- POLE2 2
- POLR3A 4
- POLR3C 4
- POLR3F 3
- POMP 2
- PRF1 4
- PRKCD 5
- PRKDC 5
- PSEN1 3
- PSENEN 3
- PSMB8 6
- PSMG2 2
- PSTPIP1 5
- PTEN 4
- PTPRC 7
- RAB27A 5
- RAC2 6
- RAD51 2
- RAD51C 2
- RAG1 7
- RAG2 7
- RANBP2 3
- RASGRP1 5
- RBCK1 5
- RECQL4 3
- REL 2
- RELA 2
- RELB 3
- RFWD3 2
- RFX5 5
- RFXANK 5
- RFXAP 5
- RHOH 3
- RIPK1 6
- RMRP 7
- RNASEH2A 5
- RNASEH2B 5
- RNASEH2C 5
- RNASEL 2
- RNF168 5
- RNF31 3
- RNU4ATAC 2
- RORC 5
- RPSA 5
- RTEL1 5
- SAMD9 2
- SAMD9L 4
- SAMHD1 5
- SBDS 6
- SEC61A1 2
- SEMA3E 3
- SERPING1 5
- SGPL1 5
- SH2D1A 5
- SH3KBP1 2
- SKIV2L 6
- SLC29A3 5
- SLC35C1 5
- SLC37A4 6
- SLC39A7 3
- SLC46A1 5
- SLC7A7 2
- SLX4 2
- SMARCAL1 5
- SMARCD2 2
- SNORA31 5
- SNX10 2
- SP110 5
- SPINK5 6
- SPPL2A 4
- SRP54 2
- SRP72 2
- STAT1 5
- STAT2 6
- STAT3 5
- STAT5B 7
- STIM1 6
- STK4 5
- STN1 2
- STX11 4
- STXBP2 5
- TAP1 5
- TAP2 5
- TAPBP 3
- TAZ 6
- TBK1 5
- TBX1 7
- TCF3 8
- TCIRG1 2
- TCN2 9
- TERC 3
- TERT 3
- TFRC 2
- TGFB1 2
- TGFBR1 2
- TGFBR2 2
- THBD 3
- TICAM1 6
- TINF2 3
- TIRAP 2
- TLR3 6
- TLR4 1
- TLR7 3
- TMC6 6
- TMC8 6
- TMEM173 7
- TMPRSS2 6
- TNF 2
- TNFAIP3 4
- TNFRSF11A 4
- TNFRSF13B 7
- TNFRSF13C 2
- TNFRSF1A 5
- TNFRSF4 2
- TNFRSF9 2
- TNFSF11 2
- TNFSF12 2
- TOP2B 2
- TP53 3
- TPP2 4
- TRAC 4
- TRAF3 3
- TRAF3IP2 3
- TREX1 4
- TRIM22 2
- TRNT1 4
- TTC37 6
- TTC7A 4
- TYK2 5
- UBE2T 2
- UNC13D 4
- UNC93B1 7
- UNG 5
- USB1 4
- USP18 4
- VPS13B 5
- VPS45 5
- WAS 8
- WDR1 4
- WIPF1 5
- WRAP53 2
- XIAP 5
- XRCC2 2
- ZAP70 6
- ZBTB24 5
- ZNF341 3
- APOE 1
- ATF3 2
- ATG16L1 2
- ATG5 2
- BECN1 2
- CCR7 2
- CD207 2
- CD28 2
- CD4 4
- CLEC4M 3
- CPT2 2
- CX3CR1 2
- CXADR 2
- CXCR3 2
- DDX58 2
- DEFA1 2
- DPP4 3
- DSG2 2
- EIF3M 2
- FCMR 2
- FEZ1 2
- FOLR1 2
- FURIN 2
- FUT2 3
- GC 3
- GNAQ 2
- GPATCH3 2
- GPR183 2
- GUCY2C 5
- IDE 2
- IFNL3 2
- IL18 3
- IL3 2
- IL7 3
- IL9 2
- ILF3 2
- ITGAM 3
- ITPKB 1
- IVNS1ABP 2
- KHDRBS1 1
- KRAS 4
- LILRB1 1
- MICA 2
- MIF 1
- MIR155 3
- MRC1 1
- MRE11 4
- MX2 2
- NECTIN1 2
- NLRP6 2
- NPC1 2
- NRAS 6
- PDGFRA 2
- PSMA3 4
- PSMB10 3
- PSMB4 5
- PSMB9 5
- PTX3 2
- PVR 2
- RC3H1 3
- SCARB1 1
- SERINC3 1
- SERINC5 1
- SLC2A1 1
- TBX21 1
- TNFSF10 1
- ABCA7 1
- ABCB1 2
- ABCC1 3
- ABI3 1
- ACE 2
- ACKR1 1
- AKT1 1
- ALOXE3 1
- ANPEP 1
- BANF1 2
- BCAR1 1
- BLOC1S6 2
- BRF2 1
- BST2 1
- CC2D2A 1
- CCL11 2
- CCL21 1
- CCL3L1 2
- CCND1 1
- CCR5 2
- CD200 1
- CD209 3
- CDKN1B 2
- CH25H 1
- CLDN6 2
- CLDN9 2
- CNBP 4
- COLEC11 3
- CR1 1
- CTSB 1
- CTSL 2
- CXorf36 1
- CYP2B6 1
- DDX1 1
- DMBT1 1
- DMD 1
- ELF4 5
- EPCAM 3
- ERAP2 1
- ERCC2 2
- ERCC3 2
- FBF1 3
- FBRS 1
- FCGR1A 3
- FCGR2B 3
- FCGR3B 5
- FCGRT 3
- FLNA 1
- FOXM1 1
- FPR3 3
- GAD1 6
- GTF2H5 1
- HBB 1
- HFE 1
- HIVEP1 1
- HLA-A 1
- HLA-C 2
- HLA-DPB1 1
- HLA-DQB1 2
- HLA-DRA 1
- HLA-DRB5 1
- HSPA5 1
- HTR2A 1
- HYDIN 1
- ICAM1 1
- IFNL4 1
- IGHG2 3
- IL22 3
- IL23A 3
- IL31RA 1
- IL4 1
- IL4R 2
- IRGM 1
- ITGAL 1
- KARS 1
- KIR2DL2 3
- KPNA2 1
- KRT18 1
- LDB2 1
- LDLR 1
- LRRC8A 5
- LY6E 1
- LYZ 2
- LZTFL1 3
- MASP1 2
- MBL2 4
- MED13L 1
- MET 1
- MIS12 1
- MLKL 1
- MPI 2
- MPP5 2
- MST1R 1
- MTOR 1
- MTPAP 1
- MUC5AC 1
- MUC5B 1
- MX1 1
- MYH9 1
- NCR3 1
- NFKBID 3
- NRP2 1
- NUP214 2
- NUP88 1
- OCLN 1
- ODC1 1
- PARP1 1
- PDCD1 1
- PHB 1
- PHB2 1
- PKD1L3 1
- PLG 1
- PQBP1 1
- PROM1 1
- PRSS1 1
- PTPN2 1
- PTPN22 1
- PYCARD 1
- RB1 1
- RET 3
- RPAIN 1
- SAMD3 1
- SART3 4
- SCN4A 1
- SCN5A 2
- SDC1 1
- SELPLG 1
- SERPINA1 1
- SGTA 1
- SH3BP2 3
- SIGIRR 1
- SLAMF6 1
- SLC11A1 1
- SLC13A4 1
- SLC1A5 1
- SLC20A2 1
- SLC6A19 1
- SLFN12 1
- SLFN12L 1
- SMAD3 1
- SOCS1 1
- SPNS3 1
- STAT4 1
- STAT5A 3
- STAT6 1
- STK17B 1
- TAPT1 1
- TLR2 1
- TLR5 1
- TMEM181 1
- TMPRSS11A 1
- TMPRSS4 1
- TNFSF4 1
- TNIP1 1
- TPH1 1
- TRBC1 2
- TRIB3 1
- TRIM69 2
- TSPAN14 1
- TUBGCP3 1
- UNC119 3
- UNC5CL 1
- VPS11 2
- VPS33A 2
- VPS4A 1
- WSCD1 1
- ZC3HC1 1
- ZFHX3 1
- ZFP36 1
- ZNF34 1
STRs in panel
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COVID-19 research
Gene: TRIM69 Red List (low evidence)
TRIM69 (tripartite motif containing 69)
EnsemblGeneIds (GRCh38): ENSG00000185880
EnsemblGeneIds (GRCh37): ENSG00000185880
OMIM: 616017, Gene2Phenotype
TRIM69 is in 1 panel
EnsemblGeneIds (GRCh38): ENSG00000185880
EnsemblGeneIds (GRCh37): ENSG00000185880
OMIM: 616017, Gene2Phenotype
TRIM69 is in 1 panel
2 reviews
Sarah Leigh (Genomics England Curator)
Comment on list classification: Not associated with phenotype in OMIM or in Gen2Phen. PMID 22105173 reports three TRIM69 variants in three cases who had had herpes simplex encephalitis during childhood. Evidence for was strong for the homozygous p.R141*, but less so for the heterozygous p.S186L, which functional studies showed was hypomorphic and not a complete loss-of-function allele, possibly explaining variable penetrance in other carriers. The third variant p.P625L was not supported by functional studies and was also present in the unaffected father of the proband.Created: 16 Jun 2020, 9:38 a.m. | Last Modified: 16 Jun 2020, 9:38 a.m.
Panel Version: 1.57
Created: 16 Jun 2020, 9:38 a.m.
Last Modified: 16 Jun 2020, 9:38 a.m.
Panel version: 1.57
Last Modified: 16 Jun 2020, 9:38 a.m.
Panel version: 1.57
Zornitza Stark (Australian Genomics)
Red List (low evidence)
One individual with bi-allelic and one individual with mono-allelic variants in this gene described.
Sources: Expert listCreated: 12 Jun 2020, 10:21 a.m.
Mode of inheritance
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Phenotypes
Susceptibility to herpes simplex encephalitis
Publications
Created: 12 Jun 2020, 10:21 a.m.
Panel version: 1.23
Panel version: 1.23
Details
- Mode of Inheritance
- BOTH monoallelic and biallelic, autosomal or pseudoautosomal
- Sources
-
- Expert Review Red
- Phenotypes
-
- Susceptibility to herpes simplex encephalitis
- OMIM
- 616017
- Clinvar variants
- Variants in TRIM69
- Penetrance
- None
- Publications
- Panels with this gene
History Filter Activity
16 Jun 2020, Gel status: 1
Entity classified by Genomics England curator
Sarah Leigh (Genomics England Curator)Gene: trim69 has been classified as Red List (Low Evidence).
12 Jun 2020, Gel status: 0
Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes
Zornitza Stark (Australian Genomics)gene: TRIM69 was added gene: TRIM69 was added to COVID-19 research. Sources: Expert list Mode of inheritance for gene: TRIM69 was set to BOTH monoallelic and biallelic, autosomal or pseudoautosomal Publications for gene: TRIM69 were set to 22105173 Phenotypes for gene: TRIM69 were set to Susceptibility to herpes simplex encephalitis Review for gene: TRIM69 was set to RED