COVID-19 research

Gene: CCL5

Comment on list classification: Based on expert review by Sophie Hambleton (Newcastle University)

Created: 11 May 2020, 4:04 p.m. | Last Modified: 11 May 2020, 4:04 p.m.

Panel Version: 0.206

Preprint https://doi.org/10.1101/2020.05.02.20084673 reports 10 terminally-ill, critical COVID-19 patients with profound elevation of plasma IL-6 and CCL5 (RANTES), decreased CD8+ T cell levels, and SARS-CoV-2 plasma viremia. Treatment with CCR5 blocking antibody leronlimab, results in complete CCR5 receptor occupancy on macrophage and T cells, rapid reduction of plasma IL-6, restoration of the CD4/CD8 ratio, and a significant decrease in SARS-CoV-2 plasma viremia. From single-cell RNA-sequencing, this effect appears to be a result of reduced transcriptomic myeloid cell clusters expressing IL-6 and interferon-related genes.

Created: 11 May 2020, 3:23 p.m. | Last Modified: 11 May 2020, 3:23 p.m.

Panel Version: 0.205

Publications

• https://doi.org/10.1101/2020.05.02.20084673

Green List (high evidence)

Makes sense to evaluate influence of variants on susceptibility to severe COVID

Created: 7 May 2020, 4:12 p.m. | Last Modified: 7 May 2020, 4:12 p.m.

Panel Version: 0.204

Comment on list classification: Updated rating from Red to Amber: Some evidence that CCL5 (aka RANTES) polymorphisms may be associated with viral infections, including SARS.

Created: 14 Apr 2020, 2:37 p.m. | Last Modified: 14 Apr 2020, 2:37 p.m.

Panel Version: 0.91

PMID:30175654 (El-Bendary et al., 2019) report rs3817655 polymorphism in CCL5 may be associated with spontaneous clearance of Hepatitis C virus (HCV).

Created: 14 Apr 2020, 2:36 p.m. | Last Modified: 14 Apr 2020, 2:36 p.m.

Panel Version: 0.89

PMID:31874580 (Sheng et al. 2019) study suggests that the CCL5 rs2107538 polymorphism was correlated with TB (infectious disease caused by Mycobacterium tuberculosis) susceptibility in Caucasians. The rs2107538 polymorphism is suggested to affect CCL5 expression.

Created: 14 Apr 2020, 2:36 p.m. | Last Modified: 14 Apr 2020, 2:36 p.m.

Panel Version: 0.89

PMID:22576913 (Al-Qahtani et al 2012) show -403G>A and -28C>G SNPs in the CCL5 (aka RANTES) gene are associated with Hepatitis B virus infection in a Saudi population.

Created: 14 Apr 2020, 2:22 p.m. | Last Modified: 14 Apr 2020, 2:22 p.m.

Panel Version: 0.88

PMID: 17540042 case-control study reporting an associated with a polymorphism in the CCL5 gene and admission to intensive care units or death due to SARS infection.
Sources: Literature

Created: 30 Mar 2020, 4:15 p.m.

Mode of inheritance
BOTH monoallelic and biallelic, autosomal or pseudoautosomal

Phenotypes
Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Infection; Susceptibility to SARS-CoV

Publications

• 17540042