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COVID-19 research

Gene: DDX58

Amber List (moderate evidence)
DDX58 (DExD/H-box helicase 58)
EnsemblGeneIds (GRCh38): ENSG00000107201
EnsemblGeneIds (GRCh37): ENSG00000107201
OMIM: 609631, Gene2Phenotype
DDX58 is in 5 panels

2 reviews

Eleanor Williams (Genomics England Curator)

Added new-gene-name tag, new approved HGNC gene symbol for DDX58 is RIGI.
Created: 21 Nov 2022, 3:24 p.m. | Last Modified: 21 Nov 2022, 3:24 p.m.
Panel Version: 1.134
Created: 21 Nov 2022, 3:24 p.m.
Last Modified: 21 Nov 2022, 3:24 p.m.
Panel version: 1.134

Sarah Leigh (Genomics England Curator)

Comment on list classification: Wild type DDX58 confers detection and eradication of replicating viral genomes, variants in this gene could therefore interfere with this mechanism.
Created: 12 May 2020, 4:54 p.m. | Last Modified: 12 May 2020, 4:54 p.m.
Panel Version: 0.223
PMID 21939710 found DDX5 (formerly known as RIGI) was essential for virus-induced expression of IRF3 and concluded that DDX5 is essential for detection and eradication of replicating viral genomes. PMID 16625202 reported that DDX58 is essential for the production of interferons in response to certain RNA viruses including paramyxoviruses, influenza virus, and Japanese encephalitis virus.
Sources: Literature
Created: 12 May 2020, 4:47 p.m.

Mode of inheritance
Unknown

Publications

Created: 12 May 2020, 4:47 p.m.

Panel version: 0.221

Details

Mode of Inheritance
Unknown
Sources
  • Expert Review Amber
  • Literature
Tags
new-gene-name
OMIM
609631
Clinvar variants
Variants in DDX58
Penetrance
None
Publications
Panels with this gene

History Filter Activity

21 Nov 2022, Gel status: 2

Added Tag

Eleanor Williams (Genomics England Curator)

Tag new-gene-name tag was added to gene: DDX58.

12 May 2020, Gel status: 2

Entity classified by Genomics England curator

Sarah Leigh (Genomics England Curator)

Gene: ddx58 has been classified as Amber List (Moderate Evidence).

12 May 2020, Gel status: 1

Set publications

Sarah Leigh (Genomics England Curator)

Publications for gene: DDX58 were set to 21939710; 16625202

12 May 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications

Sarah Leigh (Genomics England Curator)

gene: DDX58 was added gene: DDX58 was added to Viral susceptibility. Sources: Literature Mode of inheritance for gene: DDX58 was set to Unknown Publications for gene: DDX58 were set to 21939710; 16625202