COVID-19 research

Gene: MICA

Comment on list classification: MICA was identified through an OMIM search for potential viral susceptibility genes. Based on initial triage by Illumina (Tier 5 grouping) and additional curation, upgraded rating from Red to Amber: A number of publications report association between MICA variants and HBV‐related hepatocellular carcinoma. Additional papers investigate MICA polymorphisms and response to viral infections/recovery (e.g. PMIDs:28925058, 15029237).

Created: 21 May 2020, 4:21 p.m. | Last Modified: 21 May 2020, 4:21 p.m.

Panel Version: 0.273

PMID:15029237. Karacki et al., 2004 investigated whether MICA polymorphisms are associated with HCV recovery. They compared the frequency of all known MICA polymorphisms in 2 large cohorts of people who recovered from either HCV or HBV infection and controls. Of the 27 unique MICA polymorphisms examined, only one was detected more often in persons who had cleared HCV infection, compared with controls: MICA*015. However <4% of all those examined with viral clearance were MICA*015 positive. They cannot exclude the possibility that MICA*015 is tightly linked to another allele that is responsible for the association.

Created: 21 May 2020, 4:16 p.m. | Last Modified: 21 May 2020, 4:16 p.m.

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Several publications on association between MICA variants and hepatitis B virus (HBV) infection and HBV‐related hepatocellular carcinoma (PMIDs:31419949, 29584564,25270965).

Created: 21 May 2020, 4 p.m. | Last Modified: 21 May 2020, 4:01 p.m.

Panel Version: 0.270

PMID:28925058. Luo et al., 2017 examined MICA/MIBC gene polymorphisms and respiratory syncytial virus (RSV) infection in 135 paediatric patients with and without pneuomina after RSV infection. Allele MICA*002:01/A9 and haplotype MICA*002:01-MICB*005:02 were negatively associated with RSV respiratory tract infections.

Created: 21 May 2020, 3:59 p.m. | Last Modified: 21 May 2020, 3:59 p.m.

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PMID:31033131. Gong et al., 2019 report that SNP rs2523454 G>A increased the risk of persistent HBV infection in the Chinese population, through downregulation of MICA expression (rs2523454 is a MIC 5'UTR variant: https://www.ncbi.nlm.nih.gov/snp/rs2523454)

Created: 21 May 2020, 3:59 p.m. | Last Modified: 21 May 2020, 3:59 p.m.

Panel Version: 0.268

Red List (low evidence)

One of the 25 top novel PID-associated genes in a large-cohort WGS analysis, using BeviMed assessment of enrichment for candidate disease-causing variants in individual genes (https://doi.org/10.1101/499988)

Created: 19 May 2020, 3:54 p.m. | Last Modified: 19 May 2020, 3:54 p.m.

Panel Version: 0.260

Mode of inheritance
Unknown

Phenotypes
primary immunodeficiency

Publications

• https://doi.org/10.1101/499988