COVID-19 research
Gene: PLG

PLG (plasminogen)
EnsemblGeneIds (GRCh38): ENSG00000122194
EnsemblGeneIds (GRCh37): ENSG00000122194
OMIM: 173350, Gene2Phenotype
PLG is in 6 panels

1 review

Eleanor Williams (Genomics England Curator)

Red List (low evidence)

Preprint: Klaassen et al https://doi.org/10.1101/2020.05.13.093690 - performed analysis of variants in FURIN, PLG, PRSS1, TMPRSS11a, MBL2 and OAS1 genes in 143 unrelated individuals from Serbian population and identified 22 variants with potential functional effect. Then used in-silico prediction and comparative population analysis and found 6 rare variants in PLG. p.Arg261His and p.Ala494Val are predicted to be probably damaging/deleterious.
Sources: Literature
Created: 22 May 2020, 10:18 a.m.

Mode of inheritance
Unknown

Publications

https://doi.org/10.1101/2020.05.13.093690

Created: 22 May 2020, 10:18 a.m.

Panel version: 0.300

Details

Mode of Inheritance

Unknown

Sources

Literature

OMIM

173350

Clinvar variants

Variants in PLG

Penetrance

None

Publications

https://doi.org/10.1101/2020.05.13.093690

Panels with this gene

History Filter Activity

22 May 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications

Eleanor Williams (Genomics England Curator)

gene: PLG was added gene: PLG was added to COVID-19 research. Sources: Literature Mode of inheritance for gene: PLG was set to Unknown Publications for gene: PLG were set to https://doi.org/10.1101/2020.05.13.093690 Review for gene: PLG was set to RED

COVID-19 research Gene: PLG