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COVID-19 research

Gene: IRF3

Green List (high evidence)
IRF3 (interferon regulatory factor 3)
EnsemblGeneIds (GRCh38): ENSG00000126456
EnsemblGeneIds (GRCh37): ENSG00000126456
OMIM: 603734, Gene2Phenotype
IRF3 is in 2 panels

2 reviews

Louise Daugherty (Genomics England Curator)

I don't know

OriginaI Metadata from IUIS classification table (February, 2018) downloaded 20180614. IUIS Genetic defect (original gene symbol in IUIS download): IRF3 .PanelApp HGNC gene symbol check: IRF3 . IUIS Disease: IRF3 deficiency . IUIS Inheritance: AD .T cells: N/A, .B cells: N/A, .IUIS Other affected cells: CNS resident cells and fibroblasts. IUIS Associated features: Herpes simplex virus 1 encephalitis. IUIS Major category: Defects in Intrinsic and Innate Immunity. IUIS Subcategory: Herpes Simplex Encephalitis (HSE)
Created: 6 Jul 2018, 12:11 p.m.
Created: 6 Jul 2018, 12:11 p.m.

Panel version: Imported from Primary immunodeficiency panel version 0.1567

Sophie Hambleton (Newcastle University)

I don't know

2 patients, haploinsufficiency invoked
Created: 29 Jun 2018, 4:24 p.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Phenotypes
susceptibility to herpes simplex encephalitis

Publications

Created: 29 Jun 2018, 4:24 p.m.

Panel version: Imported from Primary immunodeficiency panel version 0.1370

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Sources
  • Expert Review Green
  • Expert list
  • IUIS Classification December 2019
  • IUIS Classification February 2018
Phenotypes
  • {Encephalopathy, acute, infection-induced (herpes-specific), susceptibility to, 7}, 616532
  • {Encephalopathy, acute, infection-induced (herpes-specific), susceptibility to, 7}, MIM616532
  • Herpes simplex virus 1 encephalitis
  • Defects in Intrinsic and Innate Immunity
OMIM
603734
Clinvar variants
Variants in IRF3
Penetrance
None
Publications
Panels with this gene

History Filter Activity

2 Apr 2020, Gel status: 3

Added New Source, Set Phenotypes, Status Update

Ellen McDonagh (Genomics England Curator)

Source Expert Review Green was added to IRF3. Added phenotypes {Encephalopathy, acute, infection-induced (herpes-specific), susceptibility to, 7}, 616532; Herpes simplex virus 1 encephalitis; Defects in Intrinsic and Innate Immunity for gene: IRF3 Rating Changed from Amber List (moderate evidence) to Green List (high evidence)

1 Apr 2020, Gel status: 2

Set mode of inheritance, Set Phenotypes, Set publications

Ellen McDonagh (Genomics England Curator)

Mode of inheritance for gene IRF3 was changed from MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown Added phenotypes {Encephalopathy, acute, infection-induced (herpes-specific), susceptibility to, 7}, 616532; Herpes simplex virus 1 encephalitis; Defects in Intrinsic and Innate Immunity for gene: IRF3 Publications for gene IRF3 were updated from to 32086639; 26513235; 32048120; 26216125

31 Mar 2020, Gel status: 2

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Ellen McDonagh (Genomics England Curator)

gene: IRF3 was added gene: IRF3 was added to Viral susceptibility. Sources: Expert list,Expert Review Amber Mode of inheritance for gene: IRF3 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Phenotypes for gene: IRF3 were set to {Encephalopathy, acute, infection-induced (herpes-specific), susceptibility to, 7}, MIM616532