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COVID-19 research

Gene: KARS

Red List (low evidence)
KARS (lysyl-tRNA synthetase)
EnsemblGeneIds (GRCh38): ENSG00000065427
EnsemblGeneIds (GRCh37): ENSG00000065427
OMIM: 601421, Gene2Phenotype
KARS is in 13 panels

1 review

Sarah Leigh (Genomics England Curator)

Red List (low evidence)

Using Collaborative Cross mouse genetic reference population, PMID 32348764 studied the genetic regulation of variation in antibody response to influenza A virus (IAV) infection. This enabled the identification of 23 quantitative trait loci (QTL) associated with variation in specific antibody isotypes across time points; this allowed a subset to be found that broadly affect the antibody response to IAV as well as other viruses. This gene is the equivalent human for the mouse gene that was classified as a candidate from one of the QTLs, based on the predicted variant consequences and haplotype-specific expression patterns (PMID 32348764 table 2).
Created: 27 May 2020, 10:50 a.m. | Last Modified: 27 May 2020, 10:50 a.m.
Panel Version: 0.332
New gene name for KARS is KARS1
Created: 5 May 2020, 2:52 p.m. | Last Modified: 5 May 2020, 2:52 p.m.
Panel Version: 0.189

Mode of inheritance
Unknown

Phenotypes
Influenza A Virus-Specific Antibody Responses

Publications

Created: 5 May 2020, 2:45 p.m.
Last Modified: 5 May 2020, 2:45 p.m.
Panel version: 0.332

History Filter Activity

5 May 2020, Gel status: 1

Added Tag

Sarah Leigh (Genomics England Curator)

Tag new-gene-name tag was added to gene: KARS.

5 May 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance

Sarah Leigh (Genomics England Curator)

gene: KARS was added gene: KARS was added to Viral susceptibility. Sources: Literature Mode of inheritance for gene: KARS was set to