COVID-19 research
Gene: CC2D2A

CC2D2A (coiled-coil and C2 domain containing 2A)
EnsemblGeneIds (GRCh38): ENSG00000048342
EnsemblGeneIds (GRCh37): ENSG00000048342
OMIM: 612013, Gene2Phenotype
CC2D2A is in 28 panels

1 review

Sarah Leigh (Genomics England Curator)

Red List (low evidence)

Using Collaborative Cross mouse genetic reference population, PMID 32348764 studied the genetic regulation of variation in antibody response to influenza A virus (IAV) infection. This enabled the identification of 23 quantitative trait loci (QTL) associated with variation in specific antibody isotypes across time points; this allowed a subset to be found that broadly affect the antibody response to IAV as well as other viruses. This gene is the equivalent human for the mouse gene that was classified as a candidate from one of the QTLs, based on the predicted variant consequences and haplotype-specific expression patterns (PMID 32348764 table 2).
Created: 27 May 2020, 10:50 a.m. | Last Modified: 27 May 2020, 10:50 a.m.

Panel Version: 0.332

Mode of inheritance
Unknown

Phenotypes
Influenza A Virus-Specific Antibody Responses

Publications

32348764

Created: 5 May 2020, 2:45 p.m.
Last Modified: 5 May 2020, 2:45 p.m.
Panel version: 0.332

Details

Sources

Literature

OMIM

612013

Clinvar variants

Variants in CC2D2A

Penetrance

None

Panels with this gene

History Filter Activity

5 May 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance

Sarah Leigh (Genomics England Curator)

gene: CC2D2A was added gene: CC2D2A was added to Viral susceptibility. Sources: Literature Mode of inheritance for gene: CC2D2A was set to

COVID-19 research Gene: CC2D2A